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. 1992 Dec;66(12):7538–7542. doi: 10.1128/jvi.66.12.7538-7542.1992

Neutralization of diverse human immunodeficiency virus type 1 variants by an anti-V3 human monoclonal antibody.

M K Gorny 1, A J Conley 1, S Karwowska 1, A Buchbinder 1, J Y Xu 1, E A Emini 1, S Koenig 1, S Zolla-Pazner 1
PMCID: PMC240465  PMID: 1433529

Abstract

The third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is thought to induce potent neutralizing antibodies which are generally defined as type specific and reactive with individual viral isolates. In contrast, the CD4-binding domain is thought to induce neutralizing antibodies that are group specific and capable of neutralizing all isolates of HIV-1. However, in this study, we used a panel of human monoclonal antibodies to these regions of gp120 which displays specificities and neutralizing activities that challenge these tenets. In particular, we used a human monoclonal antibody to the V3 domain with exceptionally potent and broad neutralizing activity against many diverse HIV-1 isolates. The anti-CD4-binding domain antibodies, on the other hand, showed a more restricted pattern of activity.

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Selected References

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