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. 1991 May;65(5):2691–2694. doi: 10.1128/jvi.65.5.2691-2694.1991

Polyomavirus middle tumor antigen increases responsiveness to growth factors.

L Raptis 1
PMCID: PMC240629  PMID: 2016775

Abstract

The middle tumor antigen (mT) of polyomavirus is unable to transform a clone of NIH 3T3 cells to anchorage independence (L. Raptis and J.B. Bolen, J. Virol. 63:753-758, 1989). However, this oncogene increased the responsiveness of these cells to the growth factors (alpha-like and beta-type transforming growth factors) produced by cells possessing the whole transforming region of polyomavirus. This resulted in the growth of NIH 3T3 cells, expressing mT under control of the dexamethasone-regulatable mouse mammary tumor virus promoter, in agar medium supplemented with these growth factors upon addition of the inducer. Therefore, mT, a transforming oncogene, is able to enhance the responsiveness of established cells to growth factors, a property previously attributed primarily to myc and other establishment type oncogenes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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