Skip to main content
PMC home page
Journal of Virology logoLink to Journal of Virology
. 1992 May;66(5):3247–3250. doi: 10.1128/jvi.66.5.3247-3250.1992

Transmembrane protein oligomers of caprine arthritis-encephalitis lentivirus are immunodominant in goats with progressive arthritis.

T C McGuire 1, D P Knowles Jr 1, W C Davis 1, A L Brassfield 1, T A Stem 1, W P Cheevers 1
PMCID: PMC241096  PMID: 1313930

Abstract

To dissect mechanisms of caprine arthritis-encephalitis lentivirus-induced arthritis, an undefined immunodominant viral glycoprotein, gp90 (G. C. Johnson, A. F. Barbet, P. Klevjer-Anderson, and T. C. McGuire, Infect. Immun. 41:657-665, 1983), was characterized. Monoclonal antibody to gp90 and specific antiserum to env gene products demonstrated that gp90 was a transmembrane protein (TM) dimer. Goats with progressive arthritis had high antibody titers to oligomeric and monomeric (38-kDa) TM.

Full text

PDF
3247

Images in this article

3248Image
on p.3248
3248Image
on p.3248
3248Image
on p.3248
3249Image
on p.3249

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adams D. S., Crawford T. B., Klevjer-Anderson P. A pathogenetic study of the early connective tissue lesions of viral caprine arthritis-encephalitis. Am J Pathol. 1980 May;99(2):257–278. [PMC free article] [PubMed] [Google Scholar]
  2. Adams D. S., Gogolewski R. P., Barbet A. F., Cheevers W. P. Identification of caprine arthritis-encephalitis retrovirus proteins in immunodiffusion precipitin lines. J Gen Virol. 1985 May;66(Pt 5):1139–1143. doi: 10.1099/0022-1317-66-5-1139. [DOI] [PubMed] [Google Scholar]
  3. Allan J. S., Coligan J. E., Barin F., McLane M. F., Sodroski J. G., Rosen C. A., Haseltine W. A., Lee T. H., Essex M. Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III. Science. 1985 May 31;228(4703):1091–1094. doi: 10.1126/science.2986290. [DOI] [PubMed] [Google Scholar]
  4. Cheevers W. P., Knowles D. P., Jr, Norton L. K. Neutralization-resistant antigenic variants of caprine arthritis-encephalitis lentivirus associated with progressive arthritis. J Infect Dis. 1991 Oct;164(4):679–685. doi: 10.1093/infdis/164.4.679. [DOI] [PubMed] [Google Scholar]
  5. Cheevers W. P., Knowles D. P., McGuire T. C., Cunningham D. R., Adams D. S., Gorham J. R. Chronic disease in goats orally infected with two isolates of the caprine arthritis-encephalitis lentivirus. Lab Invest. 1988 May;58(5):510–517. [PubMed] [Google Scholar]
  6. Cheevers W. P., Roberson S., Klevjer-Anderson P., Crawford T. B. Characterization of caprine arthritis-encephalitis virus: a retrovirus of goats. Arch Virol. 1981;67(1):111–117. doi: 10.1007/BF01314610. [DOI] [PubMed] [Google Scholar]
  7. Cheevers W. P., Stem T. A., Knowles D. P., McGuire T. C. Precursor polypeptides of caprine arthritis-encephalitis lentivirus structural proteins. J Gen Virol. 1988 Mar;69(Pt 3):675–681. doi: 10.1099/0022-1317-69-3-675. [DOI] [PubMed] [Google Scholar]
  8. Cohen M., Powers M., O'Connell C., Kato N. The nucleotide sequence of the env gene from the human provirus ERV3 and isolation and characterization of an ERV3-specific cDNA. Virology. 1985 Dec;147(2):449–458. doi: 10.1016/0042-6822(85)90147-3. [DOI] [PubMed] [Google Scholar]
  9. Crawford T. B., Adams D. S. Caprine arthritis-encephalitis: clinical features and presence of antibody in selected goat populations. J Am Vet Med Assoc. 1981 Apr 1;178(7):713–719. [PubMed] [Google Scholar]
  10. Crawford T. B., Adams D. S., Cheevers W. P., Cork L. C. Chronic arthritis in goats caused by a retrovirus. Science. 1980 Feb 29;207(4434):997–999. doi: 10.1126/science.6153243. [DOI] [PubMed] [Google Scholar]
  11. Crawford T. B., Adams D. S., Sande R. D., Gorham J. R., Henson J. B. The connective tissue component of the caprine arthritis-encephalitis syndrome. Am J Pathol. 1980 Aug;100(2):443–454. [PMC free article] [PubMed] [Google Scholar]
  12. Delwart E. L., Mosialos G., Gilmore T. Retroviral envelope glycoproteins contain a "leucine zipper"-like repeat. AIDS Res Hum Retroviruses. 1990 Jun;6(6):703–706. doi: 10.1089/aid.1990.6.703. [DOI] [PubMed] [Google Scholar]
  13. East N. E., Rowe J. D., Madewell B. R., Floyd K. Serologic prevalence of caprine arthritis-encephalitis virus in California goat dairies. J Am Vet Med Assoc. 1987 Jan 15;190(2):182–186. [PubMed] [Google Scholar]
  14. Ellis T. M., Wilcox G. E., Robinson W. F. Antigenic variation of caprine arthritis-encephalitis virus during persistent infection of goats. J Gen Virol. 1987 Dec;68(Pt 12):3145–3152. doi: 10.1099/0022-1317-68-12-3145. [DOI] [PubMed] [Google Scholar]
  15. Gallaher W. R., Ball J. M., Garry R. F., Griffin M. C., Montelaro R. C. A general model for the transmembrane proteins of HIV and other retroviruses. AIDS Res Hum Retroviruses. 1989 Aug;5(4):431–440. doi: 10.1089/aid.1989.5.431. [DOI] [PubMed] [Google Scholar]
  16. Gogolewski R. P., Adams D. S., McGuire T. C., Banks K. L., Cheevers W. P. Antigenic cross-reactivity between caprine arthritis-encephalitis, visna and progressive pneumonia viruses involves all virion-associated proteins and glycoproteins. J Gen Virol. 1985 Jun;66(Pt 6):1233–1240. doi: 10.1099/0022-1317-66-6-1233. [DOI] [PubMed] [Google Scholar]
  17. Hines S. A., McElwain T. F., Buening G. M., Palmer G. H. Molecular characterization of Babesia bovis merozoite surface proteins bearing epitopes immunodominant in protected cattle. Mol Biochem Parasitol. 1989 Nov;37(1):1–9. doi: 10.1016/0166-6851(89)90096-0. [DOI] [PubMed] [Google Scholar]
  18. Johnson G. C., Adams D. S., McGuire T. C. Pronounced production of polyclonal immunoglobulin G1 in the synovial fluid of goats with caprine arthritis-encephalitis virus infection. Infect Immun. 1983 Aug;41(2):805–815. doi: 10.1128/iai.41.2.805-815.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Johnson G. C., Barbet A. F., Klevjer-Anderson P., McGuire T. C. Preferential immune response to virion surface glycoproteins by caprine arthritis-encephalitis virus-infected goats. Infect Immun. 1983 Aug;41(2):657–665. doi: 10.1128/iai.41.2.657-665.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Klevjer-Anderson P., Adams D. S., Anderson L. W., Banks K. L., McGuire T. C. A sequential study of virus expression in retrovirus-induced arthritis of goats. J Gen Virol. 1984 Sep;65(Pt 9):1519–1525. doi: 10.1099/0022-1317-65-9-1519. [DOI] [PubMed] [Google Scholar]
  21. Knowles D. P., Jr, Cheevers W. P., McGuire T. C., Brassfield A. L., Harwood W. G., Stem T. A. Structure and genetic variability of envelope glycoproteins of two antigenic variants of caprine arthritis-encephalitis lentivirus. J Virol. 1991 Nov;65(11):5744–5750. doi: 10.1128/jvi.65.11.5744-5750.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Knowles D., Jr, Cheevers W., McGuire T., Stem T., Gorham J. Severity of arthritis is predicted by antibody response to gp135 in chronic infection with caprine arthritis-encephalitis virus. J Virol. 1990 May;64(5):2396–2398. doi: 10.1128/jvi.64.5.2396-2398.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Lichtensteiger C. A., Knowles D. P., Jr, McGuire T. C., Cheevers W. P. Recombinant gp135 envelope glycoproteins of caprine arthritis-encephalitis lentivirus variants inhibit homologous and heterologous variant-specific neutralizing antibodies. Virology. 1991 Nov;185(1):2–9. doi: 10.1016/0042-6822(91)90747-y. [DOI] [PubMed] [Google Scholar]
  24. McGuire T. C., Adams D. S., Johnson G. C., Klevjer-Anderson P., Barbee D. D., Gorham J. R. Acute arthritis in caprine arthritis-encephalitis virus challenge exposure of vaccinated or persistently infected goats. Am J Vet Res. 1986 Mar;47(3):537–540. [PubMed] [Google Scholar]
  25. McGuire T. C., Brassfield A. L., Davis W. C., Cheevers W. P. Antigenic and structural variation of the p28 core polypeptide of goat and sheep retroviruses. J Gen Virol. 1987 Aug;68(Pt 8):2259–2263. doi: 10.1099/0022-1317-68-8-2259. [DOI] [PubMed] [Google Scholar]
  26. McGuire T. C., Davis W. C., Brassfield A. L., McElwain T. F., Palmer G. H. Identification of Anaplasma marginale long-term carrier cattle by detection of serum antibody to isolated MSP-3. J Clin Microbiol. 1991 Apr;29(4):788–793. doi: 10.1128/jcm.29.4.788-793.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. McGuire T. C., Norton L. K., O'Rourke K. I., Cheevers W. P. Antigenic variation of neutralization-sensitive epitopes of caprine arthritis-encephalitis lentivirus during persistent arthritis. J Virol. 1988 Sep;62(9):3488–3492. doi: 10.1128/jvi.62.9.3488-3492.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Narayan O., Sheffer D., Griffin D. E., Clements J., Hess J. Lack of neutralizing antibodies to caprine arthritis-encephalitis lentivirus in persistently infected goats can be overcome by immunization with inactivated Mycobacterium tuberculosis. J Virol. 1984 Feb;49(2):349–355. doi: 10.1128/jvi.49.2.349-355.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Oberle S. M., Palmer G. H., Barbet A. F., McGuire T. C. Molecular size variations in an immunoprotective protein complex among isolates of Anaplasma marginale. Infect Immun. 1988 Jun;56(6):1567–1573. doi: 10.1128/iai.56.6.1567-1573.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Palmer G. H., McGuire T. C. Immune serum against Anaplasma marginale initial bodies neutralizes infectivity for cattle. J Immunol. 1984 Aug;133(2):1010–1015. [PubMed] [Google Scholar]
  31. Payne S. L., Rushlow K., Dhruva B. R., Issel C. J., Montelaro R. C. Localization of conserved and variable antigenic domains of equine infectious anemia virus envelope glycoproteins using recombinant env-encoded protein fragments produced in Escherichia coli. Virology. 1989 Oct;172(2):609–615. doi: 10.1016/0042-6822(89)90203-1. [DOI] [PubMed] [Google Scholar]
  32. Pinter A., Honnen W. J., Tilley S. A., Bona C., Zaghouani H., Gorny M. K., Zolla-Pazner S. Oligomeric structure of gp41, the transmembrane protein of human immunodeficiency virus type 1. J Virol. 1989 Jun;63(6):2674–2679. doi: 10.1128/jvi.63.6.2674-2679.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Pyper J. M., Clements J. E., Molineaux S. M., Narayan O. Genetic variation among lentiviruses: homology between visna virus and caprine arthritis-encephalitis virus is confined to the 5' gag-pol region and a small portion of the env gene. J Virol. 1984 Sep;51(3):713–721. doi: 10.1128/jvi.51.3.713-721.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Rey M. A., Laurent A. G., McClure J., Krust B., Montagnier L., Hovanessian A. G. Transmembrane envelope glycoproteins of human immunodeficiency virus type 2 and simian immunodeficiency virus SIV-mac exist as homodimers. J Virol. 1990 Feb;64(2):922–926. doi: 10.1128/jvi.64.2.922-926.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Saltarelli M., Querat G., Konings D. A., Vigne R., Clements J. E. Nucleotide sequence and transcriptional analysis of molecular clones of CAEV which generate infectious virus. Virology. 1990 Nov;179(1):347–364. doi: 10.1016/0042-6822(90)90303-9. [DOI] [PubMed] [Google Scholar]
  36. Woodard J. C., Gaskin J. M., Poulos P. W., MacKay R. J., Burridge M. J. Caprine arthritis-encephalitis: clinicopathologic study. Am J Vet Res. 1982 Dec;43(12):2085–2096. [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES