Skip to main content
PMC home page
Journal of Virology logoLink to Journal of Virology
. 1992 Jul;66(7):4518–4524. doi: 10.1128/jvi.66.7.4518-4524.1992

Persistent infection of rabbits with bovine immunodeficiency-like virus.

D Y Pifat 1, W H Ennis 1, J M Ward 1, M S Oberste 1, M A Gonda 1
PMCID: PMC241261  PMID: 1318416

Abstract

Chronic infection of rabbits was induced by a single intraperitoneal injection of bovine immunodeficiency-like virus (BIV)-infected cells. Ten BIV-infected animals were monitored serologically for up to 2 years. Results of serologic and virus rescue assays indicated that all animals became infected and demonstrated a rapid and sustained BIV-specific humoral response. BIV was rescued by cocultivation from spleen, lymph nodes, and peripheral blood leukocytes of infected animals. Viral DNA in immune tissues was confirmed by polymerase chain reaction amplification of BIV sequences. These data and specific immunohistochemical staining of mononuclear cells of the spleen for BIV antigen suggest that the infection is targeted to immune system cells.

Full text

PDF
4519

Images in this article

4519Image
on p.4519
4520Image
on p.4520
4521Image
on p.4521
4522Image
on p.4522

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Akagi T., Takeda I., Oka T., Ohtsuki Y., Yano S., Miyoshi I. Experimental infection of rabbits with human T-cell leukemia virus type I. Jpn J Cancer Res. 1985 Feb;76(2):86–94. [PubMed] [Google Scholar]
  2. Braun M. J., Lahn S., Boyd A. L., Kost T. A., Nagashima K., Gonda M. A. Molecular cloning of biologically active proviruses of bovine immunodeficiency-like virus. Virology. 1988 Dec;167(2):515–523. [PubMed] [Google Scholar]
  3. Burny A., Bruck C., Cleuter Y., Couez D., Deschamps J., Ghysdael J., Grégoire D., Kettmann R., Mammerickx M., Marbaix G. Bovine leukemia virus, a versatile agent with various pathogenic effects in various animal species. Cancer Res. 1985 Sep;45(9 Suppl):4578s–4582s. [PubMed] [Google Scholar]
  4. Carpenter S., Miller L. D., Alexandersen S., Whetstone C. A., VanDerMaaten M. J., Viuff B., Wannemuehler Y., Miller J. M., Roth J. A. Characterization of early pathogenic effects after experimental infection of calves with bovine immunodeficiency-like virus. J Virol. 1992 Feb;66(2):1074–1083. doi: 10.1128/jvi.66.2.1074-1083.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cullen B. R., Greene W. C. Functions of the auxiliary gene products of the human immunodeficiency virus type 1. Virology. 1990 Sep;178(1):1–5. doi: 10.1016/0042-6822(90)90373-y. [DOI] [PubMed] [Google Scholar]
  6. Cullen B. R. Human immunodeficiency virus as a prototypic complex retrovirus. J Virol. 1991 Mar;65(3):1053–1056. doi: 10.1128/jvi.65.3.1053-1056.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Filice G., Cereda P. M., Varnier O. E. Infection of rabbits with human immunodeficiency virus. Nature. 1988 Sep 22;335(6188):366–369. doi: 10.1038/335366a0. [DOI] [PubMed] [Google Scholar]
  8. Gajdusek D. C., Amyx H. L., Gibbs C. J., Jr, Asher D. M., Rodgers-Johnson P., Epstein L. G., Sarin P. S., Gallo R. C., Maluish A., Arthur L. O. Infection of chimpanzees by human T-lymphotropic retroviruses in brain and other tissues from AIDS patients. Lancet. 1985 Jan 5;1(8419):55–56. doi: 10.1016/s0140-6736(85)91011-6. [DOI] [PubMed] [Google Scholar]
  9. Gartner S., Popovic M. Macrophage tropism of HIV-1. AIDS Res Hum Retroviruses. 1990 Aug;6(8):1017–1021. doi: 10.1089/aid.1990.6.1017. [DOI] [PubMed] [Google Scholar]
  10. Garvey K. J., Oberste M. S., Elser J. E., Braun M. J., Gonda M. A. Nucleotide sequence and genome organization of biologically active proviruses of the bovine immunodeficiency-like virus. Virology. 1990 Apr;175(2):391–409. doi: 10.1016/0042-6822(90)90424-p. [DOI] [PubMed] [Google Scholar]
  11. Gendelman H. E., Narayan O., Kennedy-Stoskopf S., Kennedy P. G., Ghotbi Z., Clements J. E., Stanley J., Pezeshkpour G. Tropism of sheep lentiviruses for monocytes: susceptibility to infection and virus gene expression increase during maturation of monocytes to macrophages. J Virol. 1986 Apr;58(1):67–74. doi: 10.1128/jvi.58.1.67-74.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Gendelman H. E., Orenstein J. M., Baca L. M., Weiser B., Burger H., Kalter D. C., Meltzer M. S. The macrophage in the persistence and pathogenesis of HIV infection. AIDS. 1989 Aug;3(8):475–495. doi: 10.1097/00002030-198908000-00001. [DOI] [PubMed] [Google Scholar]
  13. Gonda M. A., Braun M. J., Carter S. G., Kost T. A., Bess J. W., Jr, Arthur L. O., Van der Maaten M. J. Characterization and molecular cloning of a bovine lentivirus related to human immunodeficiency virus. 1987 Nov 26-Dec 2Nature. 330(6146):388–391. doi: 10.1038/330388a0. [DOI] [PubMed] [Google Scholar]
  14. Gonda M. A., Wong-Staal F., Gallo R. C., Clements J. E., Narayan O., Gilden R. V. Sequence homology and morphologic similarity of HTLV-III and visna virus, a pathogenic lentivirus. Science. 1985 Jan 11;227(4683):173–177. doi: 10.1126/science.2981428. [DOI] [PubMed] [Google Scholar]
  15. Haase A. T. Pathogenesis of lentivirus infections. Nature. 1986 Jul 10;322(6075):130–136. doi: 10.1038/322130a0. [DOI] [PubMed] [Google Scholar]
  16. Haseltine W. A. Replication and pathogenesis of the AIDS virus. J Acquir Immune Defic Syndr. 1988;1(3):217–240. [PubMed] [Google Scholar]
  17. Kestler H. W., 3rd, Ringler D. J., Mori K., Panicali D. L., Sehgal P. K., Daniel M. D., Desrosiers R. C. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell. 1991 May 17;65(4):651–662. doi: 10.1016/0092-8674(91)90097-i. [DOI] [PubMed] [Google Scholar]
  18. Kieny M. P. Structure and regulation of the human AIDS virus. J Acquir Immune Defic Syndr. 1990;3(4):395–402. [PubMed] [Google Scholar]
  19. Kulaga H., Folks T. M., Rutledge R., Kindt T. J. Infection of rabbit T-cell and macrophage lines with human immunodeficiency virus. Proc Natl Acad Sci U S A. 1988 Jun;85(12):4455–4459. doi: 10.1073/pnas.85.12.4455. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Kulaga H., Folks T., Rutledge R., Truckenmiller M. E., Gugel E., Kindt T. J. Infection of rabbits with human immunodeficiency virus 1. A small animal model for acquired immunodeficiency syndrome. J Exp Med. 1989 Jan 1;169(1):321–326. doi: 10.1084/jem.169.1.321. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Leis J., Baltimore D., Bishop J. M., Coffin J., Fleissner E., Goff S. P., Oroszlan S., Robinson H., Skalka A. M., Temin H. M. Standardized and simplified nomenclature for proteins common to all retroviruses. J Virol. 1988 May;62(5):1808–1809. doi: 10.1128/jvi.62.5.1808-1809.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Meltzer M. S., Nakamura M., Hansen B. D., Turpin J. A., Kalter D. C., Gendelman H. E. Macrophages as susceptible targets for HIV infection, persistent viral reservoirs in tissue, and key immunoregulatory cells that control levels of virus replication and extent of disease. AIDS Res Hum Retroviruses. 1990 Aug;6(8):967–971. doi: 10.1089/aid.1990.6.967. [DOI] [PubMed] [Google Scholar]
  23. Miyoshi I., Yoshimoto S., Kubonishi I., Fujishita M., Ohtsuki Y., Yamashita M., Yamato K., Hirose S., Taguchi H., Niiya K. Infectious transmission of human T-cell leukemia virus to rabbits. Int J Cancer. 1985 Jan 15;35(1):81–85. doi: 10.1002/ijc.2910350113. [DOI] [PubMed] [Google Scholar]
  24. Morrow W. J., Wharton M., Lau D., Levy J. A. Small animals are not susceptible to human immunodeficiency virus infection. J Gen Virol. 1987 Aug;68(Pt 8):2253–2257. doi: 10.1099/0022-1317-68-8-2253. [DOI] [PubMed] [Google Scholar]
  25. Oberste M. S., Gonda M. A. Conservation of amino-acid sequence motifs in lentivirus Vif proteins. Virus Genes. 1992 Jan;6(1):95–102. doi: 10.1007/BF01703760. [DOI] [PubMed] [Google Scholar]
  26. Oberste M. S., Greenwood J. D., Gonda M. A. Analysis of the transcription pattern and mapping of the putative rev and env splice junctions of bovine immunodeficiency-like virus. J Virol. 1991 Jul;65(7):3932–3937. doi: 10.1128/jvi.65.7.3932-3937.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Pifat D. Y., Smith J. F. Punta Toro virus infection of C57BL/6J mice: a model for phlebovirus-induced disease. Microb Pathog. 1987 Dec;3(6):409–422. doi: 10.1016/0882-4010(87)90011-8. [DOI] [PubMed] [Google Scholar]
  28. Rasmussen L., Battles J. K., Ennis W. H., Nagashima K., Gonda M. A. Characterization of virus-like particles produced by a recombinant baculovirus containing the gag gene of the bovine immunodeficiency-like virus. Virology. 1990 Oct;178(2):435–451. doi: 10.1016/0042-6822(90)90341-n. [DOI] [PubMed] [Google Scholar]
  29. Rasmussen L., Greenwood J. D., Gonda M. A. Expression of bovine immunodeficiency-like virus envelope glycoproteins by a recombinant baculovirus in insect cells. Virology. 1992 Feb;186(2):551–561. doi: 10.1016/0042-6822(92)90021-g. [DOI] [PubMed] [Google Scholar]
  30. Steinberg H. N., Crumpacker C. S., Chatis P. A. In vitro suppression of normal human bone marrow progenitor cells by human immunodeficiency virus. J Virol. 1991 Apr;65(4):1765–1769. doi: 10.1128/jvi.65.4.1765-1769.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Takehara N., Iwahara Y., Uemura Y., Sawada T., Ohtsuki Y., Iwai H., Hoshino H., Miyoshi I. Effect of immunization on HTLV-I infection in rabbits. Int J Cancer. 1989 Aug 15;44(2):332–336. doi: 10.1002/ijc.2910440224. [DOI] [PubMed] [Google Scholar]
  32. Van der Maaten M. J., Boothe A. D., Seger C. L. Isolation of a virus from cattle with persistent lymphocytosis. J Natl Cancer Inst. 1972 Dec;49(6):1649–1657. doi: 10.1093/jnci/49.6.1649. [DOI] [PubMed] [Google Scholar]
  33. Ward J. M., O'Leary T. J., Baskin G. B., Benveniste R., Harris C. A., Nara P. L., Rhodes R. H. Immunohistochemical localization of human and simian immunodeficiency viral antigens in fixed tissue sections. Am J Pathol. 1987 May;127(2):199–205. [PMC free article] [PubMed] [Google Scholar]
  34. Whetstone C. A., VanDerMaaten M. J., Black J. W. Humoral immune response to the bovine immunodeficiency-like virus in experimentally and naturally infected cattle. J Virol. 1990 Jul;64(7):3557–3561. doi: 10.1128/jvi.64.7.3557-3561.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES