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. 1992 Jul;66(7):4597–4600. doi: 10.1128/jvi.66.7.4597-4600.1992

Molecular basis of antigenic structures of poliovirus: implications for their evolution during morphogenesis.

K Wiegers 1, R Dernick 1
PMCID: PMC241275  PMID: 1376371

Abstract

Neutralizing monoclonal antibodies against poliovirus type 1 were obtained after conventional immunization or combined in vivo-in vitro immunization. Antibody binding sites were determined by sequence analysis of neutralization-resistant mutants. Site 3 variants had several amino acid substitutions in previously unidentified positions for neutralization resistance. Evidence for a linkage of subsites 3a and 3b is presented. Some site 3b antibodies as defined previously precipitated 14S subunits, although with reduced titers.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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