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. 1991 Jul;65(7):3954–3957. doi: 10.1128/jvi.65.7.3954-3957.1991

Fitness alteration of foot-and-mouth disease virus mutants: measurement of adaptability of viral quasispecies.

M A Martínez 1, C Carrillo 1, F González-Candelas 1, A Moya 1, E Domingo 1, F Sobrino 1
PMCID: PMC241436  PMID: 1645804

Abstract

We document the rapid alteration of fitness of two foot-and-mouth disease virus (FMDV) mutants resistant to a neutralizing monoclonal antibody. Both mutants showed a selective disadvantage in BHK-21 cells when passaged in competition with their parental FMDV. Upon repeated replication of the mutants alone, they acquired a selective advantage over the parental FMDV and fixed additional genomic substitutions without reversion of the monoclonal antibody-resistant phenotype. Thus, variants that were previously kept at low frequency in the mutant spectrum of a viral quasispecies rapidly became the master sequence of a new genomic distribution and dominated the viral population.

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Selected References

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