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. 1984 Nov;48(5):1001–1003. doi: 10.1128/aem.48.5.1001-1003.1984

Inhibitory effect of sterigmatocystin and 5,6-dimethoxysterigmatocystin on ATP synthesis in mitochondria.

K Kawai, T Nakamaru, Y Nozawa, Y Maebayashi, M Yamazaki, S Natori
PMCID: PMC241665  PMID: 6508300

Abstract

The inhibitory effects of sterigmatocystin, O-methylsterigmatocystin, and 5,6-dimethoxysterigmatocystin on the ATP synthesis system in mitochondria were compared with that of aflatoxin B1, which disturbs the respiratory chain in mitochondria. Sterigmatocystin and 5,6-dimethoxysterigmatocystin were found to uncouple the oxidative phosphorylation process without causing depression of state 3 respiration. O-Methylsterigmatocystin did not exhibit uncoupling activity at the limited concentrations tested (due to its low solubility in an aqueous system). These compounds, as well as aflatoxin B1, elicited neither pseudo-energized nor energized swelling of mitochondria and did not inhibit Ca2+-induced swelling of mitochondria.

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Selected References

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