Skip to main content
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1984 Feb;60(700):125–128. doi: 10.1136/pgmj.60.700.125

Urinary iron loss in the nephrotic syndrome--an unusual cause of iron deficiency with a note on urinary copper losses.

E A Brown, B Sampson, B R Muller, J R Curtis
PMCID: PMC2417690  PMID: 6709543

Abstract

Two patients with long-standing nephrotic syndrome are described in whom urinary iron losses may have contributed towards an iron deficiency state. Seven other nephrotic patients were also studied. Increased urinary iron excretion was found in six out of nine patients and increased urinary copper excretion in all eight patients in whom it was measured. Trace metal losses in the urine in nephrotics may be important clinically.

Full text

PDF
128

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Dagg J. H., Smith J. A., Goldberg A. Urinary excretion of iron. Clin Sci. 1966 Jun;30(3):495–503. [PubMed] [Google Scholar]
  2. Ellis D. Anemia in the course of the nephrotic syndrome secondary to transferrin depletion. J Pediatr. 1977 Jun;90(6):953–955. doi: 10.1016/s0022-3476(77)80567-2. [DOI] [PubMed] [Google Scholar]
  3. Hancock D. E., Onstad J. W., Wolf P. L. Transferrin loss into the urine with hypochromic, microcytic anemia. Am J Clin Pathol. 1976 Jan;65(1):73–78. doi: 10.1093/ajcp/65.1.73. [DOI] [PubMed] [Google Scholar]
  4. Heilmeyer L., Merker H., Wetzel H. P., Klemm D., Burmeister P., Haas R. Transferrin deficiency associated with nephrotic syndrome. Ger Med Mon. 1966 Jun;11(6):219–223. [PubMed] [Google Scholar]
  5. Jensen H., Bro-Jorgensen K., Jarnum S., Olesen H., Yssing M. Transferrin metabolism in the nephrotic syndrome and in protein-losing gastroenteropathy. Scand J Clin Lab Invest. 1968;21(4):293–304. doi: 10.3109/00365516809076997. [DOI] [PubMed] [Google Scholar]
  6. Klein W. J., Jr, Metz E. N., Price A. R. Acute copper intoxication. A hazard of hemodialysis. Arch Intern Med. 1972 Apr;129(4):578–582. [PubMed] [Google Scholar]
  7. Lindeman R. D., Baxter D. J., Yunice A. A., Kraikitpanitch S. Serum concentrations and urinary excretions of zinc in cirrhosis, nephrotic syndrome and renal insufficiency. Am J Med Sci. 1978 Jan-Feb;275(1):17–31. doi: 10.1097/00000441-197801000-00002. [DOI] [PubMed] [Google Scholar]
  8. Oski F. A. Chickee, the copper. Ann Intern Med. 1970 Sep;73(3):485–486. doi: 10.7326/0003-4819-73-3-485. [DOI] [PubMed] [Google Scholar]
  9. RIFKIND D., KRAVETZ H. M., KNIGHT V., SCHADE A. L. Urinary excretion of iron-binding protein in the nephrotic syndrome. N Engl J Med. 1961 Jul 20;265:115–118. doi: 10.1056/NEJM196107202650303. [DOI] [PubMed] [Google Scholar]
  10. Temes-Montes X. L., Picaporte M. A., Herrero E., Selgas R., Beberide J. M., Martínez-Ara J., Sánchez-Sicilia L. Valores séricos y urinarios de cinc en nefropatías exteriorizadas por síndrome nefrótico o como proteinuria en rango nefrótico. Rev Clin Esp. 1980 Nov 15;159(3):159–161. [PubMed] [Google Scholar]
  11. Wiltink W. F., van Eijk H. G., Bobeck-Rutsaert M. M., Gerbrandy J., Leijnse B. Urinary iron excretion in nephrotic syndrome. Acta Haematol. 1972;47(5):269–276. doi: 10.1159/000208536. [DOI] [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES