Abstract
Two patients with severe dothiepin intoxication are described. The management of these cases is discussed and we draw attention to the prolonged elimination half-life of dothiepin and its metabolites, and the implication for treatment.
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Selected References
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- Brodie R. R., Chasseaud L. F., Crampton E. L., Hawkins D. R., Risdall P. C. High performance liquid chromatographic determination of dothiepin and northiaden in human plasma and serum. J Int Med Res. 1977;5(6):387–390. doi: 10.1177/030006057300100201. [DOI] [PubMed] [Google Scholar]
- Crome P., Dawling S., Braithwaite R. A., Masters J., Walkey R. Effect of activated charcoal on absorption of nortriptyline. Lancet. 1977 Dec 10;2(8050):1203–1205. doi: 10.1016/s0140-6736(77)90440-8. [DOI] [PubMed] [Google Scholar]
- Diaz-Buxo J. A., Farmer C. D., Chandler J. T. Hemoperfusion in the treatment of amitriptyline intoxication. Trans Am Soc Artif Intern Organs. 1978;24:699–703. [PubMed] [Google Scholar]
- Haemoperfusion in treatment of drug intoxication. Br Med J. 1978 Jan 21;1(6106):174–174. doi: 10.1136/bmj.1.6106.174. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hallstrom C., Gifford L. Antidepressant blood levels in acute overdose. Postgrad Med J. 1976 Nov;52(613):687–688. doi: 10.1136/pgmj.52.613.687. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pond S., Rosenberg J., Benowitz N. L., Takki S. Pharmacokinetics of haemoperfusion for drug overdose. Clin Pharmacokinet. 1979 Sep-Oct;4(5):329–354. doi: 10.2165/00003088-197904050-00001. [DOI] [PubMed] [Google Scholar]
- Rees J. A. Clinical interpretation of pharmacokinetic data on dothiepin hydrochloride (Dosulepin, Prothiaden). J Int Med Res. 1981;9(2):98–102. doi: 10.1177/030006058100900202. [DOI] [PubMed] [Google Scholar]
- Trafford A., Sharpstone P., O'Neal H. Haemoperfusion in tricyclic antidepressant poisoning. Lancet. 1980 Jan 19;1(8160):155–155. [PubMed] [Google Scholar]