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. 1985 Apr;61(714):357–359. doi: 10.1136/pgmj.61.714.357

Primary hepatocellular carcinoma associated with Wilson's disease in a young woman.

R Guan, C J Oon, P K Wong, W C Foong, A Wee
PMCID: PMC2418234  PMID: 2991870

Abstract

A 27 year old woman with hepato-lenticular degeneration (Wilson's disease) was found to have primary hepatocellular carcinoma (PHC) three and a half years after she was started on treatment with D-penicillamine. The tumour was resected since when she has remained well. Her liver function tests were normal throughout the course of her disease. The available literature is reviewed and possible mechanisms for this association proposed.

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Selected References

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  1. Deiss A., Lynch R. E., Lee G. R., Cartwright G. E. Long-term therapy of Wilson's disease. Ann Intern Med. 1971 Jul;75(1):57–65. doi: 10.7326/0003-4819-75-1-57. [DOI] [PubMed] [Google Scholar]
  2. EDMONDSON H. A., STEINER P. E. Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer. 1954 May;7(3):462–503. doi: 10.1002/1097-0142(195405)7:3<462::aid-cncr2820070308>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
  3. Edwards C. R., Besser G. M., Thorner M. O. Bromocriptine-responsive form of idiopathic oedema. Lancet. 1979 Jul 14;2(8133):94–94. doi: 10.1016/s0140-6736(79)90141-7. [DOI] [PubMed] [Google Scholar]
  4. Girard P. F., Vachon A., Tommasi M., Paliard P., Rochet M., Barthe J. Dégénérescence hépato-lenticulaire et cancer primtif du foie. Lyon Med. 1968 Apr 28;219(17):1395–passim. [PubMed] [Google Scholar]
  5. HOWELL J. S. The effect of copper acetate on p-dimethylaminoazobenzene carcinogenesis in the rat. Br J Cancer. 1958 Dec;12(4):594–608. doi: 10.1038/bjc.1958.67. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kamakura K., Kimura S., Igarashi S., Fujiwara K., Toshitsugu O. [A case of Wilson's disease with hepatoma (author's transl)]. Nihon Naika Gakkai Zasshi. 1975 Mar 10;64(3):232–238. doi: 10.2169/naika.64.232. [DOI] [PubMed] [Google Scholar]
  7. Kamamoto Y., Makiura S., Sugihara S., Hiasa Y., Arai M. The inhibitory effect of copper on DL-ethionine carcinogenesis in rats. Cancer Res. 1973 May;33(5):1129–1135. [PubMed] [Google Scholar]
  8. Krasner N., Johnson P. J., Portmann B., Watkinson G., Macsween R. N., Williams R. Hepatocellular carcinoma in primary biliary cirrhosis: report of four cases. Gut. 1979 Mar;20(3):255–258. doi: 10.1136/gut.20.3.255. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. LYGREN T. Hepatolenticular degeneration (Wilson's disease) and juvenile cirrhosis in the same family. Lancet. 1959 Feb 7;1(7067):275–276. doi: 10.1016/s0140-6736(59)90202-8. [DOI] [PubMed] [Google Scholar]
  10. Mallet L., Petite J. P., Amat D., Bloch F., Juillet Y., Camilléri J. P., Housset E. Carcinome hépatocellulaire au cours de la cirrhose biliaire primitive. Une observation. Gastroenterol Clin Biol. 1981 Apr;5(4):379–384. [PubMed] [Google Scholar]
  11. Sternlieb I., Van den Hamer C. J., Morell A. G., Alpert S., Gregoriadis G., Scheinberg I. H. Lysosomal defect of hepatic copper excretion in Wilson's disease (hepatolenticular degeneration). Gastroenterology. 1973 Jan;64(1):99–105. [PubMed] [Google Scholar]
  12. Terris G., de la Lande P., Vaury P. Carcinome hépatocellulaire et cirrhose biliaire primitive : une nouvelle observation. Gastroenterol Clin Biol. 1982 Jun-Jul;6(6-7):593–594. [PubMed] [Google Scholar]
  13. Wilkinson M. L., Portmann B., Williams R. Wilson's disease and hepatocellular carcinoma: possible protective role of copper. Gut. 1983 Aug;24(8):767–771. doi: 10.1136/gut.24.8.767. [DOI] [PMC free article] [PubMed] [Google Scholar]

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