Abstract
Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy are described in a 61-year-old diabetic patient who presented wit hypoglycaemic coma. These features have not previously been reported as side effects of glibenclamide therapy, but intrahepatic cholestasis may occur with chlorpropamide, a similar sulphonylurea agent. The mechanism of this cholestasis is not clear at present.
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- Aumüller W., Bänder A., Heerdt R., Muth K., Pfaff W., Schmidt F. H., Weber H., Weyer R. Ein neues hochwirksames orales Antidiabeticum. Arzneimittelforschung. 1966 Dec;16(12):1640–1641. [PubMed] [Google Scholar]
- BELL R. J. PULMONARY INFILTRATION WITH EOSINOPHILS CAUSED BY CHLORPROPAMIDE. Lancet. 1964 Jun 6;1(7345):1249–1250. doi: 10.1016/s0140-6736(64)91872-0. [DOI] [PubMed] [Google Scholar]
- Boyle D., Hadden D. R., Bhatia S. K., Montgomery D. A., Weaver J. A. Ischaemic heart-disease in diabetics. A prospective study. Lancet. 1972 Feb 12;1(7746):338–339. doi: 10.1016/s0140-6736(72)92839-5. [DOI] [PubMed] [Google Scholar]
- Burns F. H. Clinical experience with glynclamide, a new hypoglycaemic agent. Med J Aust. 1969 Aug 30;2(9):436–439. [PubMed] [Google Scholar]
- Clarke B. F., Campbell I. W., Ewing D. J., Beveridge G. W., MacDonald M. K. Generalized hypersensitivity reaction and visceral arteritis with fatal outcome during glibenclamide therapy. Diabetes. 1974 Sep;23(9):739–742. doi: 10.2337/diab.23.9.739. [DOI] [PubMed] [Google Scholar]
- Gottesbüren H., Gerdes H., Littmann K. P., Martini G. A. Severe hypoglycaemia after glibenclamide. Lancet. 1970 Sep 12;2(7672):576–576. doi: 10.1016/s0140-6736(70)91393-0. [DOI] [PubMed] [Google Scholar]
- Hadden D. R., Montgomery D. A., Weaver J. A. Myocardial infarction in maturity-onset diabetics. A retrospective study. Lancet. 1972 Feb 12;1(7746):335–338. doi: 10.1016/s0140-6736(72)92838-3. [DOI] [PubMed] [Google Scholar]
- Harris E. L. Adverse reactions to oral antidiabetic agents. Br Med J. 1971 Jul 3;3(5765):29–30. doi: 10.1136/bmj.3.5765.29. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Powell T., Howells L. Diabetes mellitus treated with chlorpropamide and tolbutamide. A four-year clinical study. Diabetes. 1966 Apr;15(4):269–275. doi: 10.2337/diab.15.4.269. [DOI] [PubMed] [Google Scholar]
- REICHEL J., GOLDBERG S. B., ELLENBERG M., SCHAFFNER F. Intrahepatic cholestasis following administration of chlorpropamide. Report of a case with electron microscopic observations. Am J Med. 1960 Apr;28:654–660. doi: 10.1016/0002-9343(60)90161-3. [DOI] [PubMed] [Google Scholar]
- Ravid M., Rubinstein E., Cabili S. Anaphylactic reaction to chlorpropamide. Br Med J. 1971 Jul 17;3(5767):162–162. doi: 10.1136/bmj.3.5767.162. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Recker R. R., Hynes H. E. Pure red blood cell aplasia associated with chlorpropamide therapy. Patient summary and review of the literature. Arch Intern Med. 1969 Apr;123(4):445–447. [PubMed] [Google Scholar]
- Shaw K. M., Bloom A., Bulpitt C. J. Glibenclamide and nocturia. Br Med J. 1977 May 28;1(6073):1415–1415. doi: 10.1136/bmj.1.6073.1415. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sillence D. O., Court J. M. Letter: Glibenclamide-induced hypoglycaemia. Br Med J. 1975 Aug 23;3(5981):490–491. doi: 10.1136/bmj.3.5981.490-c. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Weissman P. N., Shenkman L., Gregerman R. I. Chlorpropamide hyponatremia: drug-induced inappropriate antidiuretic-hormone activity. N Engl J Med. 1971 Jan 14;284(2):65–71. doi: 10.1056/NEJM197101142840202. [DOI] [PubMed] [Google Scholar]
- Zucker P., Simon G. Prolonged symptomatic neonatal hypoglycemia associated with maternal chlorpropamide therapy. Pediatrics. 1968 Nov;42(5):824–825. [PubMed] [Google Scholar]