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. 1978 Feb;54(628):65–67. doi: 10.1136/pgmj.54.628.65

Penetration into bone and tissues of clindamycin phosphate.

P Baird, S Hughes, M Sullivan, I Willmot
PMCID: PMC2425068  PMID: 634877

Abstract

Clindamycin phosphate is an antibiotic which is effective against both Staphylococcus aureus and the anaerobic organisms. In thirteen patients, its concentration following joint replacement was measured by the agar diffusion method. In bone, the concentration was (mean +/- s.e. mean) 5.01 microgram/ml +/- 1.16, N=10; in capsule, 3.29 microgram/ml +/- 0.71, N=12; measured between 1.75 and 3.75 hr after intramuscular and intravenous injections, and in drainage fluid it amounted to 4.61 microgram/ml +/- 0.38, N=11 in 48 hr. Two patients developed diarrhoea which settled within a short period.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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