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. 1978 Jul;54(633):451–461. doi: 10.1136/pgmj.54.633.451

Prognosis and possible presymptomatic manifestations of congestive cardiomyopathy (COCM).

H Kuhn, G Breithardt, H J Knieriem, E Köhler, B Lösse, L Seipel, F Loogen
PMCID: PMC2425119  PMID: 704515

Abstract

In order to find evidence of prognosis and of presymptomatic manifestation of congestive cardiomyopathy (COCM) in fifty-eight patients, the extent of morphological changes of endomyocardial catheter biopsy (EMCB), clinical and haemodynamic data were correlated to the clinical course. In addition, clinical, haemodynamic, angiographic, morphological and His-bundle electrographic studies were performed in patients with left bundle branch block (LBBB), normal left ventricular end-diastolic volume, and normal coronary arteries (n = 43). Related to a 10-year mortality rate of 70% from the onset of symptoms, COCM is one of the most severe heart diseases. Endomyocardial catheter biopsy (EMCB) allowed clear prognostic separation in patients with COCM and seems to be of diagnostic value in patients with only slightly enlarged hearts and in patients with a short history of symptoms. The studies also revealed much evidence that at least some patients with LBBB, normal left ventricular end-diastolic volume (LVEDV) and normal coronary arteries exhibit an early stage of COCM. In these patients especially EMCB with severe changes of heart muscle cells and/or impaired left ventricular function may indicate subsequent COCM. So that there is now a new indication for performing EMCB.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blondeau M. Le bloc complet de la branche gauche avec forte déviation axiale gauche de QRS. Arch Mal Coeur Vaiss. 1974 Jun;67(6):635–645. [PubMed] [Google Scholar]
  2. Bonzel T., Schmidt H., Sigwart U., Mertens H. M., Gleichmann U. Pulmonalarteriendrücke und linksventrikulärer enddiastolischer Druck in Ruhe und unter dynamischer Belastung. Vergleichende Untersuchungen zur Druckübertragung im kleinen Kreislauf bei simultaner Messung. Z Kardiol. 1976 Dec;65(12):1088–1108. [PubMed] [Google Scholar]
  3. Bouhour J. B., Petitier H., De Lajartre A. Y., Almazor M., Nicolas G., Horeau J. La biopsie myocardique dans les myocardiopathies congestives en apparence primitives. Arch Mal Coeur Vaiss. 1976 May;69(5):485–494. [PubMed] [Google Scholar]
  4. CUTLER S. J., EDERER F. Maximum utilization of the life table method in analyzing survival. J Chronic Dis. 1958 Dec;8(6):699–712. doi: 10.1016/0021-9681(58)90126-7. [DOI] [PubMed] [Google Scholar]
  5. Friedman S. M. Lithium substitution and the distribution of sodium in the rat tail artery. Circ Res. 1974 Feb;34(2):168–175. doi: 10.1161/01.res.34.2.168. [DOI] [PubMed] [Google Scholar]
  6. Goodwin J. F., Oakley C. M. The cardiomyopathies. Br Heart J. 1972 Jun;34(6):545–552. doi: 10.1136/hrt.34.6.545. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Haerten K., Both A., Krelhaus W., Loogen F. Die Hämodynamik des kleinen Kreislaufs bei Herzgesunden unter menhrstufiger Ergometerbeilastung. Med Welt. 1976 Dec 3;27(49):2386–2388. [PubMed] [Google Scholar]
  8. Hughes H. C., Jr, Brownlee R. R., Tyers G. F. Failure of demand pacing with small surface area electrodes. Circulation. 1976 Jul;54(1):128–132. doi: 10.1161/01.cir.54.1.128. [DOI] [PubMed] [Google Scholar]
  9. Kuhn H., Breithardt G., Knieriem H. J., Loogen F., Both A., Schmidt W. A., Stroobandt R., Gleichmann U. Die Bedeutung der endomyokardialen Katheterbiopsie für die Diagnostik und die Beurteilung der Prognose der kongestiven Kardiomyopathie. Dtsch Med Wochenschr. 1975 Apr 4;100(14):717–717. doi: 10.1055/s-0028-1106283. [DOI] [PubMed] [Google Scholar]
  10. Kuhn H., Breithardt L. K., Breithardt G., Seipel L., Loogen F. Die Bedeutung des Elektrokardiogramms für die Diagnose und Verlaufsbeobachtung von Patienten mit kongestiver Kardiomyopathie. Z Kardiol. 1974 Oct;63(10):916–927. [PubMed] [Google Scholar]
  11. Kuhn H., Kübler W., Loogen F., Gleichmann U. Die kongestive Kardiomyopathie. Med Welt. 1973 Jun 15;24(24):996–998. [PubMed] [Google Scholar]
  12. Kuhn H., Loogen F. Die Wirkung von Alkohol auf das Herz einschliesslich der Alkoholkardiomyopathie. Internist (Berl) 1978 Feb;19(2):97–106. [PubMed] [Google Scholar]
  13. Kuhn H., Pfitzer P., Stoepel K. DNA content and DNA synthesis in the myocardium of rats after induced renal hypertension. Cardiovasc Res. 1974 Jan;8(1):86–91. doi: 10.1093/cvr/8.1.86. [DOI] [PubMed] [Google Scholar]
  14. Scherlag B. J., Lau S. H., Helfant R. H., Berkowitz W. D., Stein E., Damato A. N. Catheter technique for recording His bundle activity in man. Circulation. 1969 Jan;39(1):13–18. doi: 10.1161/01.cir.39.1.13. [DOI] [PubMed] [Google Scholar]
  15. Stapleton J. F., Segal J. P., Harvey W. P. The electrocardiogram of myocardopathy. Prog Cardiovasc Dis. 1970 Nov;13(3):217–239. doi: 10.1016/0033-0620(70)90001-0. [DOI] [PubMed] [Google Scholar]

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