Skip to main content
PMC home page
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1979 Feb;55(640):135–142. doi: 10.1136/pgmj.55.640.135

The human enteric coronaviruses.

S K Clarke, E O Caul, S I Egglestone
PMCID: PMC2425376  PMID: 461276

Abstract

A coronarirus was seen in the faeces from 15 (4.2%) of 355 adults with diarrhoea and from 5 (5.2%) of 96 adults without diarrhoea. Similar particles were seen in the faeces from 5 (2.2%) of 227 children aged 1--14 years with gastroenteritis, but in none of those from 230 infants under one year of age with gastroenteritis. There was no evidence that the coronavirus was responsible for any of 34 outbreaks of gastroenteritis, although it possibly caused diarrhoea in patients admitted to a psycho-geriatric unit. Excretion of the virus often continued for many months. One strain was propagated in human embryo kidney monolayers and human embryo intestinal organ cultures, although serial passage could not be accomplished.

Full text

PDF
139

Images in this article

137Fig. 1
on p.137
137Fig. 2
on p.137
138Fig. 3
on p.138
139Fig. 4
on p.139
139Fig. 5
on p.139
140Fig. 6
on p.140

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexander D. J., Gough R. E. Isolation of avian infectious bronchitis virus from experimentally infected chickens. Res Vet Sci. 1977 Nov;23(3):344–347. [PubMed] [Google Scholar]
  2. BERRY D. M., CRUICKSHANK J. G., CHU H. P., WELLS R. J. THE STRUCTURE OF INFECTIOUS BRONCHITIS VIRUS. Virology. 1964 Jul;23:403–407. doi: 10.1016/0042-6822(64)90263-6. [DOI] [PubMed] [Google Scholar]
  3. Bass E. P., Sharpee R. L. Coronavirus and gastroenteritis in foals. Lancet. 1975 Oct 25;2(7939):822–822. doi: 10.1016/S0140-6736(75)80058-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Binn L. N., Lazar E. C., Keenan K. P., Huxsoll D. L., Marchwicki R. H., Strano A. J. Recovery and characterization of a coronavirus from military dogs with diarrhea. Proc Annu Meet U S Anim Health Assoc. 1974;(78):359–366. [PubMed] [Google Scholar]
  5. Bridger J. C., Caul E. O., Egglestone S. I. Replication of an enteric bovine coronavirus in intestinal organ cultures. Arch Virol. 1978;57(1):43–51. doi: 10.1007/BF01315636. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Broderson J. R., Murphy F. A., Hierholzer J. C. Lethal enteritis in infant mice caused by mouse hepatitis virus. Lab Anim Sci. 1976 Oct;26(5):824–824. [PubMed] [Google Scholar]
  7. Caul E. O., Ashley C. R., Egglestone S. I. Recognition of human enteric coronaviruses by electron microscopy. Med Lab Sci. 1977 Jul;34(3):259–263. [PubMed] [Google Scholar]
  8. Caul E. O., Clarke S. K. Coronavirus propagated from patient with non-bacterial gastroenteritis. Lancet. 1975 Nov 15;2(7942):953–954. doi: 10.1016/S0140-6736(75)90363-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Caul E. O., Egglestone S. I. Further studies on human enteric coronaviruses. Arch Virol. 1977;54(1-2):107–117. doi: 10.1007/BF01314383. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Caul E. O., Paver W. K., Clarke S. K. Letter: Coronavirus particles in faeces from patients with gastroenteritis. Lancet. 1975 May 24;1(7917):1192–1192. doi: 10.1016/S0140-6736(75)93176-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Harkness J. W., Bracewell C. D. Morphological variation among avian infectious bronchitis virus strains. Res Vet Sci. 1974 Jan;16(1):128–131. [PubMed] [Google Scholar]
  12. Mathan M., Mathan V. I., Swaminathan S. P., Yesudoss S. Pleomorphic virus-like particles in human faeces. Lancet. 1975 May 10;1(7915):1068–1069. doi: 10.1016/S0140-6736(75)91832-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Mebus C. A., Stair E. L., Rhodes M. B., Twiehaus M. J. Neonatal calf diarrhea: propagation, attenuation, and characteristics of a coronavirus-like agent. Am J Vet Res. 1973 Feb;34(2):145–150. [PubMed] [Google Scholar]
  14. Moore B., Lee P., Hewish M., Dixon B., Mukherjee T. Coronaviruses in training centre for intellectually retarded. Lancet. 1977 Jan 29;1(8005):261–261. doi: 10.1016/S0140-6736(77)91064-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Munn E. A., Feinstein A., Munro A. J. Electron microscope examination of free IgA molecules and of their complexes with antigen. Nature. 1971 Jun 25;231(5304):527–529. doi: 10.1038/231527a0. [DOI] [PubMed] [Google Scholar]
  16. Panigrahy B., Naqi S. A., Hall C. F. Isolation and characterization of viruses associated with transmissible enteritis (bluecomb) of turkeys. Avian Dis. 1973 Apr-Jun;17(2):430–438. [PubMed] [Google Scholar]
  17. Pensaert M., Haelterman E. O., Burnstein T. Transmissible gastroenteritis of swine: virus-intestinal cell interactions. I. Immunofluorescence, histopathology and virus production in the small intestine through the course of infection. Arch Gesamte Virusforsch. 1970;31(3):321–334. doi: 10.1007/BF01253767. [DOI] [PubMed] [Google Scholar]
  18. Pensaert M., Haelterman E. O., Hinsman E. J. Transmissible gastroenteritis of swine: virus-intestinal cell interactions. II. Electron microscopy of the epithelium in isolated jejunal loops. Arch Gesamte Virusforsch. 1970;31(3):335–351. doi: 10.1007/BF01253768. [DOI] [PubMed] [Google Scholar]
  19. Schnagl R. D., Holmes I. H., Moore B., Lee P., Gust I. D., Dickinson-Jones F. An extensive rotavirus outbreak in aboriginal infants in central Australia. Med J Aust. 1977 Feb 19;1(8):259–260. doi: 10.5694/j.1326-5377.1977.tb130671.x. [DOI] [PubMed] [Google Scholar]
  20. Stair E. L., Rhodes M. B., White R. G., Mebus C. A. Neonatal calf diarrhea: purification and electron microscopy of a coronavirus-like agent. Am J Vet Res. 1972 Jun;33(6):1147–1156. [PubMed] [Google Scholar]
  21. Tajima M. Morphology of transmissible gastroenteritis virus of pigs. A possible member of coronaviruses. Brief report. Arch Gesamte Virusforsch. 1970;29(1):105–108. doi: 10.1007/BF01253886. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Tyrrell D. A., Alexander D. J., Almeida J. D., Cunningham C. H., Easterday B. C., Garwes D. J., Hierholzer J. C., Kapikian A., Macnaughton M. R., McIntosh K. Coronaviridae: second report. Intervirology. 1978;10(6):321–328. doi: 10.1159/000148996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Woode G. N., Bridger J. C. Viral enteritis of calves. Vet Rec. 1975 Jan 25;96(4):85–88. doi: 10.1136/vr.96.4.85. [DOI] [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES