Abstract
Initial intensive combined chemotherapy, with late re-operation when indicated, appears to give better results than immediate excision of the infected valve. The combination chemotherapy used in this series was amphotericin B (up to 100 mg/patient/day) and flucytosine (up to 12 g/patient/day). Serious side effects attributed to this chemotherapy were extremely rare. Candida infections were the most common and the Aspergillus infections were uniformly fatal. Embolectomies and excisions of large mycotic aneurysms were generally successful. Re-operation for late valve malfunction was common and yielded satisfactory results.
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Selected References
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- Barratt-Boyes B. G., Roche A. H. A review of aortic valve homografts over a six and one-half year period. Ann Surg. 1969 Sep;170(3):483–492. doi: 10.1097/00000658-196909010-00016. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lockey E., Al-Janabi N., Gonzalez-Lavin L., Ross D. N. A method of sterilizing and preserving fresh allograft heart valves. Thorax. 1972 Jul;27(4):398–400. doi: 10.1136/thx.27.4.398. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stinson E. B., Angell W. W., Iben A. B., Shumway N. E. Aortic valve replacement with the fresh valve homograft. Am J Surg. 1968 Aug;116(2):204–209. doi: 10.1016/0002-9610(68)90494-7. [DOI] [PubMed] [Google Scholar]
- Wain W. H., Pearce H. M., Riddell R. W., Ross D. N. A re-evaluation of antibiotic sterilisation of heart valve allografts. Thorax. 1977 Dec;32(6):740–742. doi: 10.1136/thx.32.6.740. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Waterworth P. M., Lockey E., Berry E. M., Pearce H. M. A critical investigation into the antibiotic sterilization of heart valve homografts. Thorax. 1974 Jul;29(4):432–436. doi: 10.1136/thx.29.4.432. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yacoub M., Knight E., Towers M. Proceedings: Aortic valve replacement using fresh unstented homografts. Thoraxchir Vask Chir. 1973 Oct;21(5):451–457. doi: 10.1055/s-0028-1099071. [DOI] [PubMed] [Google Scholar]