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. 1979 Nov;55(649):780–783. doi: 10.1136/pgmj.55.649.780

A comparative study of adverse factors in meningococcaemia and meningococcal meningitis

B M Ansari, D B Davies, J M H Boyce
PMCID: PMC2425795  PMID: 118439

Abstract

In a retrospective study, a comparison was made of clinical and laboratory data in 14 patients with meningococcaemia and 40 patients with meningococcal meningitis. Significant differences were found in duration of symptoms, onset of purpura, presence of shock, initial WBC, ESR, and serum fibrin degradation products. The overall mortality rate in this series was 7%, 4 patients with meningococcaemia dying, but none with meningococcal meningitis. This study indicates the importance of clinical and pathological grading of patients with meningococcaemia. Death occurred only in patients presenting with 3 or more of the adverse factors detailed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blum D., Fondu P., Denolin-Reubens R., Dubois J. Early heparin therapy in 60 children with acute meningococcemia. Relationship between clinical manifestations and coagulation abnormalities. Acta Chir Belg. 1973 Jul;72(4):288–297. [PubMed] [Google Scholar]
  2. Corrigan J. J., Jr, Jordan C. M. Heparin therapy in septicemia with disseminated intravascular coagulation. N Engl J Med. 1970 Oct 8;283(15):778–782. doi: 10.1056/NEJM197010082831502. [DOI] [PubMed] [Google Scholar]
  3. Evans R. W., Glick B., Kimball F., Bobell M. Fatal intravascular consumption coagulopathy in meningococcal sepsis. Am J Med. 1969 Jun;46(6):910–918. doi: 10.1016/0002-9343(69)90093-x. [DOI] [PubMed] [Google Scholar]
  4. Filkins J. P., Di Luzio N. R. Heparin protection in endotoxin shock. Am J Physiol. 1968 May;214(5):1074–1077. doi: 10.1152/ajplegacy.1968.214.5.1074. [DOI] [PubMed] [Google Scholar]
  5. Fox B. Disseminated intravascular coagulation and the Waterhouse-Friderichsen syndrome. Arch Dis Child. 1971 Oct;46(249):680–685. doi: 10.1136/adc.46.249.680. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hunter J. Heparin therapy in meningococcal septicaemia. Arch Dis Child. 1973 Mar;48(3):233–235. doi: 10.1136/adc.48.3.233. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. MARGARETTEN W., McADAMS A. J. An appraisal of fulminant meningococcemia with reference to the Shartzman phenomenon. Am J Med. 1958 Dec;25(6):868–876. doi: 10.1016/0002-9343(58)90059-7. [DOI] [PubMed] [Google Scholar]
  8. Margaretten W., Csavossy I., McKay D. G. An electron miscroscope study of a case of meningococcemia in man. Am J Dis Child. 1967 Sep;114(3):268–277. doi: 10.1001/archpedi.1967.02090240082005. [DOI] [PubMed] [Google Scholar]
  9. McGehee W. G., Rapaport S. I., Hjort P. F. Intravascular coagulation in fulminant meningococcemia. Ann Intern Med. 1967 Aug;67(2):250–260. doi: 10.7326/0003-4819-67-2-250. [DOI] [PubMed] [Google Scholar]
  10. STERNBERG S. D., ZWEIFLER B. M., GRUBER S., LICHTERMAN J. The Shwartzman phenomenon complicating acute meningococcemia with meningitis. J Pediatr. 1951 Mar;38(3):369–374. doi: 10.1016/s0022-3476(51)80058-1. [DOI] [PubMed] [Google Scholar]
  11. Stiehm E. R., Damrosch D. S. Factors in the prognosis of meningococcal infection. Review of 63 cases with emphasis on recognition and management of the severely ill patient. J Pediatr. 1966 Mar;68(3):457–467. doi: 10.1016/s0022-3476(66)80250-0. [DOI] [PubMed] [Google Scholar]

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