Abstract
The antifibrinolytic drug tranexamic acid was assessed in controlling bleeding in 12 patients with left-sided proctocolitis. The study was designed as a double-blind cross-over trial employing a dose of 4·5 g of tranexamic acid/day together with identical placebo. A statistically significant reduction in rectal bleeding was achieved in 50% of cases with a minimum of side effects. Sigmoidoscopic grading of rectal mucosal appearances was improved. Frequency of diarrhoea and stool consistency were not altered.
Tranexamic acid may have a part to play in the management of selected patients with ulcerative colitis in whom bleeding is difficult to control with orthodox treatment.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ASTRUP T., MULLERTZ S. The fibrin plate method for estimating fibrinolytic activity. Arch Biochem Biophys. 1952 Oct;40(2):346–351. doi: 10.1016/0003-9861(52)90121-5. [DOI] [PubMed] [Google Scholar]
- Hills M., Armitage P. The two-period cross-over clinical trial. Br J Clin Pharmacol. 1979 Jul;8(1):7–20. doi: 10.1111/j.1365-2125.1979.tb05903.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kluft C. Occurrence of C1 inactivator and other proteinase inhibitors in euglobulin fractions and their influence on fibrinolytic activity. Haemostasis. 1976;5(3):136–146. doi: 10.1159/000214129. [DOI] [PubMed] [Google Scholar]
- Kwaan H. C., Cocco A., Mendeloff A. I., Astrup T. Fibrinolytic activity in the normal and inflamed rectal mucosa. Scand J Gastroenterol. 1969;4(5):441–445. doi: 10.3109/00365526909180630. [DOI] [PubMed] [Google Scholar]
- Mowat N. A., Douglas A. S., Brunt P. W., McIntosh J. A., King P. C., Boddy K. Epsilon-aminocaproic acid therapy in ulcerative colitis. Am J Dig Dis. 1973 Nov;18(11):959–965. doi: 10.1007/BF01072440. [DOI] [PubMed] [Google Scholar]
- Ormerod T. P. Anaemia in ulcerative colitis. Proc R Soc Med. 1968 Sep;61(9):931–931. [PMC free article] [PubMed] [Google Scholar]
- Pandolfi M., Astrup T. A histochemical study of the fibrinolytic activity. Cornea, conjunctiva, and lacrimal gland. Arch Ophthalmol. 1967 Feb;77(2):258–264. doi: 10.1001/archopht.1967.00980020260022. [DOI] [PubMed] [Google Scholar]
- Salter R. H., Read A. E. Epsilon-aminocaproic acid therapy in ulcerative colitis. Gut. 1970 Jul;11(7):585–587. doi: 10.1136/gut.11.7.585. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Swan C. H., Williams J. A., Cooke W. T. Fibinolysis in colonic disease. Gut. 1970 Jul;11(7):588–591. doi: 10.1136/gut.11.7.588. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Walker I. D., Davidson J. F., Hutton I. "Fibrinolytic potential": the response to a 5 minute venous occlusion test. Thromb Res. 1976 May;8(5):629–638. doi: 10.1016/0049-3848(76)90244-9. [DOI] [PubMed] [Google Scholar]