Skip to main content
PMC home page
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1990 May;66(775):356–362. doi: 10.1136/pgmj.66.775.356

Antiphospholipid antibodies and Mycoplasma pneumoniae infection.

N Snowden 1, P B Wilson 1, M Longson 1, R S Pumphrey 1
PMCID: PMC2426843  PMID: 2371184

Abstract

Anticardiolipin antibody levels were measured in 57 patients with Mycoplasma pneumoniae infection and 21 patients with other infections. Significantly more patients in the mycoplasma group had increased IgM and IgG anticardiolipin. Within the mycoplasma group significantly higher titres were found in patients with severe infection (assessed by need for hospital admission) and in patients with cold agglutinins. A tendency for particularly high titres to occur in patients with extra-pulmonary complications was identified.

Full text

PDF
358

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ali N. J., Sillis M., Andrews B. E., Jenkins P. F., Harrison B. D. The clinical spectrum and diagnosis of Mycoplasma pneumoniae infection. Q J Med. 1986 Mar;58(227):241–251. [PubMed] [Google Scholar]
  2. Asherson R. A., Harris E. N. Anticardiolipin antibodies--clinical associations. Postgrad Med J. 1986 Dec;62(734):1081–1087. doi: 10.1136/pgmj.62.734.1081. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Carreras L. O., Defreyn G., Machin S. J., Vermylen J., Deman R., Spitz B., Van Assche A. Arterial thrombosis, intrauterine death and "lupus" antiocoagulant: detection of immunoglobulin interfering with prostacyclin formation. Lancet. 1981 Jan 31;1(8214):244–246. doi: 10.1016/s0140-6736(81)92087-0. [DOI] [PubMed] [Google Scholar]
  4. Colaço C. B., Male D. K. Anti-phospholipid antibodies in syphilis and a thrombotic subset of SLE: distinct profiles of epitope specificity. Clin Exp Immunol. 1985 Feb;59(2):449–456. [PMC free article] [PubMed] [Google Scholar]
  5. Derksen R. H., Biesma D., Bouma B. N., Gmelig Meyling F. H., Kater L. Discordant effects of prednisone on anticardiolipin antibodies and the lupus anticoagulant. Arthritis Rheum. 1986 Oct;29(10):1295–1296. doi: 10.1002/art.1780291021. [DOI] [PubMed] [Google Scholar]
  6. Derksen R. H., Hasselaar P., Blokzijl L., Gmelig Meyling F. H., De Groot P. G. Coagulation screen is more specific than the anticardiolipin antibody ELISA in defining a thrombotic subset of lupus patients. Ann Rheum Dis. 1988 May;47(5):364–371. doi: 10.1136/ard.47.5.364. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Dowd A. B., Grace R., Rees W. D. Cerebral infarction associated with Mycoplasma pneumoniae infection. Lancet. 1987 Sep 5;2(8558):567–567. doi: 10.1016/s0140-6736(87)92950-3. [DOI] [PubMed] [Google Scholar]
  8. Drew P., Asherson R. A., Zuk R. J., Goodwin F. J., Hughes G. R. Aortic occlusion in systemic lupus erythematosus associated with antiphospholipid antibodies. Ann Rheum Dis. 1987 Aug;46(8):612–616. doi: 10.1136/ard.46.8.612. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Harris E. N., Asherson R. A., Hughes G. R. Antiphospholipid antibodies--autoantibodies with a difference. Annu Rev Med. 1988;39:261–271. doi: 10.1146/annurev.me.39.020188.001401. [DOI] [PubMed] [Google Scholar]
  10. Harris E. N., Gharavi A. E., Patel S. P., Hughes G. R. Evaluation of the anti-cardiolipin antibody test: report of an international workshop held 4 April 1986. Clin Exp Immunol. 1987 Apr;68(1):215–222. [PMC free article] [PubMed] [Google Scholar]
  11. Harris E. N., Gharavi A. E., Tincani A., Chan J. K., Englert H., Mantelli P., Allegro F., Ballestrieri G., Hughes G. R. Affinity purified anti-cardiolipin and anti-DNA antibodies. J Clin Lab Immunol. 1985 Aug;17(4):155–162. [PubMed] [Google Scholar]
  12. Hughes G. R., Harris N. N., Gharavi A. E. The anticardiolipin syndrome. J Rheumatol. 1986 Jun;13(3):486–489. [PubMed] [Google Scholar]
  13. Isenberg D. A., Maddison P., Swana G., Skinner R. P., Swana M., Jones M., Addison I., Dudeney C., Shall S., el Roiey A. Profile of autoantibodies in the serum of patients with tuberculosis, klebsiella and other gram-negative infections. Clin Exp Immunol. 1987 Mar;67(3):516–523. [PMC free article] [PubMed] [Google Scholar]
  14. Klemp P., Cooper R. C., Strauss F. J., Jordaan E. R., Przybojewski J. Z., Nel N. Anti-cardiolipin antibodies in ischaemic heart disease. Clin Exp Immunol. 1988 Nov;74(2):254–257. [PMC free article] [PubMed] [Google Scholar]
  15. Loizou S., McCrea J. D., Rudge A. C., Reynolds R., Boyle C. C., Harris E. N. Measurement of anti-cardiolipin antibodies by an enzyme-linked immunosorbent assay (ELISA): standardization and quantitation of results. Clin Exp Immunol. 1985 Dec;62(3):738–745. [PMC free article] [PubMed] [Google Scholar]
  16. Manoussakis M. N., Tzioufas A. G., Silis M. P., Pange P. J., Goudevenos J., Moutsopoulos H. M. High prevalence of anti-cardiolipin and other autoantibodies in a healthy elderly population. Clin Exp Immunol. 1987 Sep;69(3):557–565. [PMC free article] [PubMed] [Google Scholar]
  17. McHugh N. J., Maymo J., Skinner R. P., James I., Maddison P. J. Anticardiolipin antibodies, livedo reticularis, and major cerebrovascular and renal disease in systemic lupus erythematosus. Ann Rheum Dis. 1988 Feb;47(2):110–115. doi: 10.1136/ard.47.2.110. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Misra R., Venables P. J., Watkins R. P., Maini R. N. Autoimmunity to cardiolipin in infectious mononucleosis. Lancet. 1987 Sep 12;2(8559):629–629. doi: 10.1016/s0140-6736(87)93019-4. [DOI] [PubMed] [Google Scholar]
  19. Oppenheimer S., Hoffbrand B. I. Optic neuritis and myelopathy in systemic lupus erythematosus. Can J Neurol Sci. 1986 May;13(2):129–132. doi: 10.1017/s0317167100036064. [DOI] [PubMed] [Google Scholar]
  20. Syrjänen J., Valtonen V. V., Iivanainen M., Kaste M., Huttunen J. K. Preceding infection as an important risk factor for ischaemic brain infarction in young and middle aged patients. Br Med J (Clin Res Ed) 1988 Apr 23;296(6630):1156–1160. doi: 10.1136/bmj.296.6630.1156. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Twomey J. A., Espir M. L. Neurological manifestations and mycoplasma pneumoniae infection. Br Med J. 1979 Oct 6;2(6194):832–833. doi: 10.1136/bmj.2.6194.832. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Vaarala O., Palosuo T., Kleemola M., Aho K. Anticardiolipin response in acute infections. Clin Immunol Immunopathol. 1986 Oct;41(1):8–15. doi: 10.1016/0090-1229(86)90046-2. [DOI] [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES