Abstract
Of the precancerous conditions of the mouth, leukoplakia is the most common, and it was considered likely that the long-term follow-up of patients would yield valuable information for the control and treatment of the condition.
A study of the histories of 324 patients, in whom leukoplakia had been diagnosed sometime during the previous 23 years, showed that there was a relationship between smoking and the frequency of leukoplakia. Alcohol, mechanical irritants and electric potential difference in the mouth were also important etiological factors, particularly in combination. Many of the cases with mild symptoms improved when the etiological agent was removed.
The cases were classified into groups according to whether there were signs of keratinized mucosa, verrucous proliferations or ulcerated white lesions. The more severe cases more frequently developed carcinomas and were treated by surgery.
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Selected References
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- Einhorn J., Wersall J. Incidence of oral carcinoma in patients with leukoplakia of the oral mucosa. Cancer. 1967 Dec;20(12):2189–2193. doi: 10.1002/1097-0142(196712)20:12<2189::aid-cncr2820201218>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
- Mela F., Mongini F. Contributo casistico allo studio delle leucoplachie orali. Indagine clinica di controllo su 141 casi sottoposti a biopsia. Minerva Stomatol. 1966 Jul;15(7):502–507. [PubMed] [Google Scholar]
- PINDBORG J. J., RENSTRUP G., POULSEN H. E., SILVERMAN S., Jr STUDIES IN ORAL LEUKOPLAKIAS. V. CLINICAL AND HISTOLOGIC SIGNS OF MALIGNANCY. Acta Odontol Scand. 1963 Nov;21:407–414. doi: 10.3109/00016356309028203. [DOI] [PubMed] [Google Scholar]
- Pindborg J. J., Jolst O., Renstrup G., Roed-Petersen B. Studies in oral leukoplakia: a preliminary report on the period pervalence of malignant transformation in leukoplakia based on a follow-up study of 248 patients. J Am Dent Assoc. 1968 Apr;76(4):767–771. doi: 10.14219/jada.archive.1968.0127. [DOI] [PubMed] [Google Scholar]
- SHAFER W. G., WALDRON C. A. A clinical and histopathologic study of oral leukoplakia. Surg Gynecol Obstet. 1961 Apr;112:411–420. [PubMed] [Google Scholar]