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. 1969;41(6):761–769.

Smallpox vaccination by intradermal jet injection*

2. Cutaneous and serological responses to primary vaccination in children

Ronald R Roberto, Herta Wulff, J Donald Millar
PMCID: PMC2427591  PMID: 5309529

Abstract

Primary vaccination by intradermal jet injection, using diluted smallpox vaccine, was compared with multiple-pressure vaccination in 625 Jamaican children. The cutaneous and antibody response patterns were evaluated. The primary take rates among those jet vaccinated were 97% or more in those receiving vaccines with a titre of 106.3 TCID50/ml and 107.0TCID50/ml, and 96% in those vaccinated by multiple pressure, using undiluted vaccine. The primary take rates in subjects receiving jet-injected vaccine with titres of 106.0 TCID50/ml and 105.0 TCID50/ml were 90% and 62%, respectively. Among subjects tested who developed Jennerian vesicles, all but 3 demonstrated seroconversion. In those who failed to develop primary Jennerian vesicles, there was also a failure of neutralizing-antibody development. Vesicle and scar sizes were generally smaller in the jet-vaccinated subjects than in those vaccinated by the multiple-pressure technique. Infants tolerated jet vaccination without difficulty. Vaccinial complications did not occur in any subject. The intradermal jet injection of 0.1 ml of vaccine with a titre 106.3 TCID50/ml or higher is recommended as a highly effective method for achieving successful primary smallpox vaccination. The method appears best suited for use in mass smallpox-vaccination programmes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CUTCHINS E., WARREN J., JONES W. P. The antibody response to smallpox vaccination as measured by a tissue culture plaque method. J Immunol. 1960 Sep;85:275–283. [PubMed] [Google Scholar]
  2. DOWNIE A. W., HOBDAY T. L., ST VINCENT L., KEMPE C. H. Studies of smallpox antibody levels of sera from samples of the vaccinated adult population of Madras. Bull World Health Organ. 1961;25:55–61. [PMC free article] [PubMed] [Google Scholar]
  3. ELISBERG B. L., MCCOWN J. M., SMADEL J. E. Vaccination against smallpox. II. Jet injection of chorio-allantoic membrane vaccine. J Immunol. 1956 Nov;77(5):340–351. [PubMed] [Google Scholar]
  4. ESPMARK J. A., LINDAHL J., LJUNGGREN A., WERNER B. ANTIBODY RESPONSE AFTER "ATYPICALLY" PERFORMED SMALLPOX VACCINATION. Acta Pathol Microbiol Scand. 1965;64:95–102. doi: 10.1111/apm.1965.64.1.95. [DOI] [PubMed] [Google Scholar]
  5. MEYER H. M., Jr, HOSTETLER D. D., Jr, BERNHEIN B. C., ROGERS N. G., LAMBIN P., CHASSARY A., LABUSQUIERE R., SMADEL J. E. RESPONSE OF VOLTA CHILDREN TO JET INOCULATION OF COMBINED LIVE MEASLES, SMALLPOX AND YELLOW FEVER VACCINES. Bull World Health Organ. 1964;30:783–794. [PMC free article] [PubMed] [Google Scholar]
  6. McCARTHY K., DOWNIE A. W., BRADLEY W. H. The antibody response in man following infection with viruses of the pox group. II. Antibody response following vaccination. J Hyg (Lond) 1958 Dec;56(4):466–478. doi: 10.1017/s0022172400037979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Millar J. D., Roberto R. R., Wulff H., Wenner H. A., Henderson D. A. Smallpox vaccination by intradermal jet injection. I. Introduction, background and results of pilot studies. Bull World Health Organ. 1969;41(6):749–760. [PMC free article] [PubMed] [Google Scholar]

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