Abstract
The double-stranded complex of polyriboinosinic acid and polyribocytidilic acid (poly I·poly C) was shown to inhibit effectively the infection of human cells with 4 common human respiratory pathogens—influenza A2, rhinovirus 13, respiratory syncytial and parainfluenza-1 viruses. This protection was observed with levels of poly I·poly C which did not induce the release of detectable amounts of interferon. Mice could be protected from pulmonary influenza A2 infections by intranasal instillation of poly I·poly C before challenge with virus. Administration of poly I·poly C directly to the respiratory tract was found superior to systemic administration in the case of the pulmonary infection studied.
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Selected References
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