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. 1987 Sep;63(743):801–804. doi: 10.1136/pgmj.63.743.801

The significance of pancytopenia in miliary tuberculosis.

B J Hunt 1, V Andrews 1, K W Pettingale 1
PMCID: PMC2428536  PMID: 3444806

Abstract

Patients with miliary tuberculosis accompanied by a pancytopenia rarely survive their disease. If the peripheral blood picture does recover it has been taken as an indication that there is no underlying haematological disease, and so re-examination of the bone marrow is not performed. A case is described where resolution of the pancytopenia occurred but a persisting haematological disease remained. Aspects of haematological disease associated with tuberculosis are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BIEHL J. P. Miliary tuberculosis; a review of sixty-eight adult patients admitted to a municipal general hospital. Am Rev Tuberc. 1958 Apr;77(4):605–622. doi: 10.1164/artpd.1958.77.4.605. [DOI] [PubMed] [Google Scholar]
  2. COOPER W. Pancytopenia associated with disseminated tuberculosis. Ann Intern Med. 1959 Jun;50(6):1497–1501. doi: 10.7326/0003-4819-50-6-1497. [DOI] [PubMed] [Google Scholar]
  3. Coburn R. J., England J. M., Samson D. M., Walford D. M., Blowers R., Chanarin I., Levi A. J., Slavin G. Tuberculosis and blood disorders. Br J Haematol. 1973 Dec;25(6):793–799. doi: 10.1111/j.1365-2141.1973.tb01791.x. [DOI] [PubMed] [Google Scholar]
  4. Glasser R. M., Walker R. I., Herion J. C. The significance of hematologic abnormalities in patients with tuberculosis. Arch Intern Med. 1970 Apr;125(4):691–695. [PubMed] [Google Scholar]
  5. KALINOWSKI S. Z., WALKER J. M. Thrombocytopenic purpura in tuberculosis. Br J Tuberc Dis Chest. 1956 Jul;50(3):239–243. doi: 10.1016/s0366-0869(56)80030-0. [DOI] [PubMed] [Google Scholar]
  6. Katzen H., Spagnolo S. V. Bone marrow necrosis from miliary tuberculosis. JAMA. 1980 Nov 28;244(21):2438–2439. [PubMed] [Google Scholar]
  7. MEDD W. E., HAYHOE F. G. Tuberculous miliary necrosis with pancytopenia. Q J Med. 1955 Oct;24(96):351–364. [PubMed] [Google Scholar]
  8. Mangion P. D., Schiller K. F. Disseminated tuberculosis complicated by pancytopenia. Proc R Soc Med. 1971 Sep;64(9):1000–1000. [PMC free article] [PubMed] [Google Scholar]
  9. Mufti G. J., Figes A., Hamblin T. J., Oscier D. G., Copplestone J. A. Immunological abnormalities in myelodysplastic syndromes. I. Serum immunoglobulins and autoantibodies. Br J Haematol. 1986 May;63(1):143–147. doi: 10.1111/j.1365-2141.1986.tb07504.x. [DOI] [PubMed] [Google Scholar]
  10. Munt P. W. Miliary tuberculosis in the chemotherapy era: with a clinical review in 69 American adults. Medicine (Baltimore) 1972 Mar;51(2):139–155. doi: 10.1097/00005792-197203000-00004. [DOI] [PubMed] [Google Scholar]
  11. O'BRIEN J. R. Non-reactive tuberculosis. J Clin Pathol. 1954 Aug;7(3):216–225. doi: 10.1136/jcp.7.3.216. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Pitchenik A. E., Cole C., Russell B. W., Fischl M. A., Spira T. J., Snider D. E., Jr Tuberculosis, atypical mycobacteriosis, and the acquired immunodeficiency syndrome among Haitian and non-Haitian patients in south Florida. Ann Intern Med. 1984 Nov;101(5):641–645. doi: 10.7326/0003-4819-101-5-641. [DOI] [PubMed] [Google Scholar]
  13. Rosenberg M. J., Rumans L. W. Survival of a patient with pancytopenia and disseminated coagulation associated with miliary tuberculosis. Chest. 1978 Apr;73(4):536–539. doi: 10.1378/chest.73.4.536. [DOI] [PubMed] [Google Scholar]
  14. Sahn S. A., Neff T. A. Miliary tuberculosis. Am J Med. 1974 Apr;56(4):494–505. doi: 10.1016/0002-9343(74)90482-3. [DOI] [PubMed] [Google Scholar]
  15. Tricot G., Boogaerts M. A., De Wolf-Peeters C., Van den Berghe H., Verwilghen R. L. The myelodysplastic syndromes: different evolution patterns based on sequential morphological and cytogenetic investigations. Br J Haematol. 1985 Apr;59(4):659–670. doi: 10.1111/j.1365-2141.1985.tb07361.x. [DOI] [PubMed] [Google Scholar]
  16. Weintraub M., Siegman-Igra Y., Josiphov J., Rahmani R., Liron M. Histiocytic hemophagocytosis in miliary tuberculosis. Arch Intern Med. 1984 Oct;144(10):2055–2056. [PubMed] [Google Scholar]
  17. Zamorano J., Jr, Tompsett R. Disseminated atypical mycobacterial infection and pancytopenia. Arch Intern Med. 1968 May;121(5):424–427. [PubMed] [Google Scholar]

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