Abstract
Liver involvement in typhoid fever is uncommon. Typhoid hepatitis is now being recognized as a definite entity. Over a period of 4 years, we have observed 10 cases (4.8%) of typhoid hepatitis out of 210 cases of typhoid fever. Jaundice, anaemia, hepatomegaly and abnormal biochemical tests were present in all cases. Liver biopsy was done in 8 cases and was found to be abnormal in 5. Two of the 10 cases of typhoid hepatitis died. Recognition of typhoid hepatitis is important since it has to be differentiated from other common ailments in the tropics such as viral, malarial or amoebic hepatitis. Early institution of specific therapy in cases of typhoid hepatitis carries a good prognosis.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ayhan A., Gokoz A., Karacadag S., Telatar H. The liver in typhoid fever. Am J Gastroenterol. 1973 Feb;59(2):141–146. [PubMed] [Google Scholar]
- Butler T., Bell W. R., Levin J., Linh N. N., Arnold K. Typhoid fever. Studies of blood coagulation, bacteremia, and endotoxemia. Arch Intern Med. 1978 Mar;138(3):407–410. doi: 10.1001/archinte.138.3.407. [DOI] [PubMed] [Google Scholar]
- Dagli A. J., Lulla S. B., Nagle S. B., Sirkar S. Typhoid hepatitis. J Assoc Physicians India. 1984 Mar;32(3):302–303. [PubMed] [Google Scholar]
- Greig H. B., Naidoo P. D. A case of typhoid fever complicated by a severe bleeding syndrome due to deficiency of the prothrombin group of coagulation factors. J Trop Med Hyg. 1981 Dec;84(6):253–257. [PubMed] [Google Scholar]
- Kar P., Bhargava D. K., Tandon B. N. Enteric hepatitis. J Assoc Physicians India. 1985 Jun;33(6):417–418. [PubMed] [Google Scholar]
- Khosla S. N., Singh R., Singh G. P., Trehan V. K. The spectrum of hepatic injury in enteric fever. Am J Gastroenterol. 1988 Apr;83(4):413–416. [PubMed] [Google Scholar]
- Khosla S. N., Srivastava S. C., Gupta S. Neuro-psychiatric manifestations of typhoid. J Trop Med Hyg. 1977 May;80(5):95–98. [PubMed] [Google Scholar]
- Nasrallah S. M., Nassar V. H. Enteric fever: a clinicopathologic study of 104 cases. Am J Gastroenterol. 1978 Jan;69(1):63–69. [PubMed] [Google Scholar]
- Ramachandran S., Godfrey J. J., Perera M. V. Typhoid hepatitis. JAMA. 1974 Oct 14;230(2):236–240. [PubMed] [Google Scholar]
- Rao P. N., Bhusnurmath S. R., Naik S. R. Typhoid fever manifesting with haematemesis, hepatitis and haemolysis. J Trop Med Hyg. 1978 Aug;81(8):146–150. [PubMed] [Google Scholar]
- Singh D. S. Typhoid hepatitis. J Assoc Physicians India. 1985 Sep;33(9):621–621. [PubMed] [Google Scholar]