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. 1991 Apr;35(4):785–787. doi: 10.1128/aac.35.4.785

Disulfiram inhibits the in vitro growth of methicillin-resistant staphylococcus aureus.

M Phillips 1, G Malloy 1, D Nedunchezian 1, A Lukrec 1, R G Howard 1
PMCID: PMC245102  PMID: 2069390

Abstract

Several antibiotics have disulfiram-like effects; we evaluated disulfiram for its antibiotic-like effects. Disulfiram inhibited the in vitro growth of methicillin-resistant Staphylococcus aureus, with an MIC of 1.33 micrograms/ml, but was not effective against members of the family Enterobacteriaceae or Pseudomonas species.

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Selected References

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  1. Agarwal R. P., McPherson R. A., Phillips M. Rapid degradation of disulfiram by serum albumin. Res Commun Chem Pathol Pharmacol. 1983 Nov;42(2):293–310. [PubMed] [Google Scholar]
  2. Carper W. R., Dorey R. C., Beber J. H. Inhibitory effect of disulfiram (Antabuse) on alcohol dehydrogenase activity. Clin Chem. 1987 Oct;33(10):1906–1908. [PubMed] [Google Scholar]
  3. Cobby J., Mayersohn M., Selliah S. The rapid reduction of disulfiram in blood and plasma. J Pharmacol Exp Ther. 1977 Sep;202(3):724–731. [PubMed] [Google Scholar]
  4. Das Gupta V. Stability of aqueous suspensions of disulfiram. Am J Hosp Pharm. 1981 Mar;38(3):363–364. [PubMed] [Google Scholar]
  5. Deitrich R. A. Diphosphopyridine nucleotide-linked aldehyde dehydrogenase. 3. Sulfhydryl characteristics of the enzyme. Arch Biochem Biophys. 1967 Mar;119(1):253–263. doi: 10.1016/0003-9861(67)90452-3. [DOI] [PubMed] [Google Scholar]
  6. Elenbaas R. M., Ryan J. L., Robinson W. A., Singsank M. J., Harvey M. J., Klaassen C. D. On the disulfiram-like activity of moxalactam. Clin Pharmacol Ther. 1982 Sep;32(3):347–355. doi: 10.1038/clpt.1982.170. [DOI] [PubMed] [Google Scholar]
  7. Eneanya D. I., Bianchine J. R., Duran D. O., Andresen B. D. The actions of metabolic fate of disulfiram. Annu Rev Pharmacol Toxicol. 1981;21:575–596. doi: 10.1146/annurev.pa.21.040181.003043. [DOI] [PubMed] [Google Scholar]
  8. Gerrein J. R., Rosenberg C. M., Manohar V. Disulfiram maintenance in outpatient treatment of alcoholism. Arch Gen Psychiatry. 1973 Jun;28(6):798–802. doi: 10.1001/archpsyc.1973.01750360034004. [DOI] [PubMed] [Google Scholar]
  9. Grandjean P., Kristensen K., Jørgensen P. J., Nielsen G. D., Andersen O. Trace element status in alcoholism before and during disulfiram treatment. Ann Clin Lab Sci. 1990 Jan-Feb;20(1):28–35. [PubMed] [Google Scholar]
  10. Johansson B. Rapid and sensitive on-line precolumn purification and high-performance liquid chromatographic assay for disulfiram and its metabolites. J Chromatogr. 1986 Jun 13;378(2):419–429. doi: 10.1016/s0378-4347(00)80737-9. [DOI] [PubMed] [Google Scholar]
  11. Kannangara D. W., Gallagher K., Lefrock J. L. Disulfiram-like reactions with newer cephalosporins: cefmenoxime. Am J Med Sci. 1984 Mar-Apr;287(2):45–47. doi: 10.1097/00000441-198403000-00012. [DOI] [PubMed] [Google Scholar]
  12. Kitson T. M. The disulfiram--ethanol reaction: a review. J Stud Alcohol. 1977 Jan;38(1):96–113. doi: 10.15288/jsa.1977.38.96. [DOI] [PubMed] [Google Scholar]
  13. Lang J. M., Touraine J. L., Trepo C., Choutet P., Kirstetter M., Falkenrodt A., Herviou L., Livrozet J. M., Retornaz G., Touraine F. Randomised, double-blind, placebo-controlled trial of ditiocarb sodium ('Imuthiol') in human immunodeficiency virus infection. Lancet. 1988 Sep 24;2(8613):702–706. doi: 10.1016/s0140-6736(88)90184-5. [DOI] [PubMed] [Google Scholar]
  14. Lukrec A., Phillips M., Howard R. G. Inhibition of serum lactate dehydrogenase activity by disulfiram and diethyldithiocarbamate. Biochem Pharmacol. 1989 Sep 15;38(18):3132–3133. doi: 10.1016/0006-2952(89)90029-4. [DOI] [PubMed] [Google Scholar]
  15. Lundwall L., Baekeland F. Disulfiram treatment of alcoholism. J Nerv Ment Dis. 1971 Dec;153(6):381–394. doi: 10.1097/00005053-197112000-00002. [DOI] [PubMed] [Google Scholar]
  16. Marshall M. J., Harris A. M., Horne J. E. The bacteriological and clinical assessment of a new preparation of the treatment of otitis externa in dogs and cats. J Small Anim Pract. 1974 Jun;15(6):401–410. doi: 10.1111/j.1748-5827.1974.tb06514.x. [DOI] [PubMed] [Google Scholar]
  17. Musacchio J. M., Goldstein M., Anagnoste B., Poch G., Kopin I. J. Inhibition of dopamine-beta-hydroxylase by disulfiram in vivo. J Pharmacol Exp Ther. 1966 Apr;152(1):56–61. [PubMed] [Google Scholar]
  18. Reisinger E. C., Kern P., Ernst M., Bock P., Flad H. D., Dietrich M. Inhibition of HIV progression by dithiocarb. German DTC Study Group. Lancet. 1990 Mar 24;335(8691):679–682. doi: 10.1016/0140-6736(90)90802-c. [DOI] [PubMed] [Google Scholar]
  19. Scheibel L. W., Adler A., Trager W. Tetraethylthiuram disulfide (Antabuse) inhibits the human malaria parasite Plasmodium falciparum. Proc Natl Acad Sci U S A. 1979 Oct;76(10):5303–5307. doi: 10.1073/pnas.76.10.5303. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Sellers E. M., Naranjo C. A., Peachey J. E. Drug therapy: Drugs to decrease alcohol consumption. N Engl J Med. 1981 Nov 19;305(21):1255–1262. doi: 10.1056/NEJM198111193052105. [DOI] [PubMed] [Google Scholar]
  21. Taylor E. H., Walker E. M., Jr, Bartelt M., Day S., Pappas A. A. In vitro antimicrobial activity of diethyldithiocarbamate and dimethyldithiocarbamate against methicillin-resistant Staphylococcus. Ann Clin Lab Sci. 1987 May-Jun;17(3):171–177. [PubMed] [Google Scholar]

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