Abstract
Trospectomycin is an aminocyclitol analog of spectinomycin with significant in vitro activity against Chlamydia trachomatis. A single 1-g intramuscular dose was administered to 10 men with symptomatic, culture-positive chlamydial urethritis. Trospectomycin was well tolerated but failed to eradicate chlamydial infection, as determined by cultures obtained approximately 1 week after treatment.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Csángó P. A., Gundersen T., Martinsen I. M. Effect of amoxicillin on simultaneous Chlamydia trachomatis infection in men with gonococcal urethritis: comparison of three dosage regimens. Sex Transm Dis. 1985 Apr-Jun;12(2):93–96. doi: 10.1097/00007435-198504000-00009. [DOI] [PubMed] [Google Scholar]
- Ehret J. M., Judson F. N. Susceptibility testing of Chlamydia trachomatis: from eggs to monoclonal antibodies. Antimicrob Agents Chemother. 1988 Sep;32(9):1295–1299. doi: 10.1128/aac.32.9.1295. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lassus A., Renkonen O. V., Ellmén J. Fleroxacin versus standard therapy in gonococcal urethritis. J Antimicrob Chemother. 1988 Oct;22 (Suppl 500):223–225. doi: 10.1093/jac/22.supplement_d.223. [DOI] [PubMed] [Google Scholar]
- Loo P. S., Ridgway G. L., Oriel J. D. Single dose ciprofloxacin for treating gonococcal infections in men. Genitourin Med. 1985 Oct;61(5):302–305. doi: 10.1136/sti.61.5.302. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Oriel J. D., Loo P., Felmingham D. Treatment of Neisseria gonorrhoeae infections in men with single-dose thiamphenicol. Sex Transm Dis. 1984 Oct-Dec;11(4 Suppl):410–413. doi: 10.1097/00007435-198410001-00025. [DOI] [PubMed] [Google Scholar]
- Oriel J. D., Ridgway G. L., Goldmeier D., Felmingham D. Treatment of gonococcal urethritis in men with a rifampicin-erythromycin combination. Sex Transm Dis. 1982 Oct-Dec;9(4):208–211. doi: 10.1097/00007435-198210000-00011. [DOI] [PubMed] [Google Scholar]
- Oriel J. D., Ridgway G. L., Reeve P., Beckingham D. C., Owen J. The lack of effect of ampicillin plus probenecid given for genital infections with Neisseria gonorrhoeae on associated infections with Chlamydia trachomatis. J Infect Dis. 1976 May;133(5):568–571. doi: 10.1093/infdis/133.5.568. [DOI] [PubMed] [Google Scholar]
- Reichman R. C., Nolte F. S., Wolinsky S. M., Greisberger C. A., Trupei M. A., Nitzkin J. Single-dose cefuroxime axetil in the treatment of uncomplicated gonorrhea: a controlled trial. Sex Transm Dis. 1985 Oct-Dec;12(4):184–187. doi: 10.1097/00007435-198510000-00003. [DOI] [PubMed] [Google Scholar]
- Schachter J. Chlamydial infections (third of three parts). N Engl J Med. 1978 Mar 9;298(10):540–549. doi: 10.1056/NEJM197803092981005. [DOI] [PubMed] [Google Scholar]
- Singal S. S., Reichman R. C., Graman P. S., Greisberger C., Trupei M. A., Menegus M. A. Isolation of Chlamydia trachomatis from men with urethritis: relative value of one vs. two swabs and influence of concomitant gonococcal infection. Sex Transm Dis. 1986 Jan-Mar;13(1):50–52. doi: 10.1097/00007435-198601000-00011. [DOI] [PubMed] [Google Scholar]
- Taylor-Robinson D., Evans R. T., Coufalik E. D., Oates J. K. Effect of short term treatment of non-gonococcal urethritis with minocycline. Genitourin Med. 1986 Feb;62(1):19–23. doi: 10.1136/sti.62.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zurenko G. E., Yagi B. H., Vavra J. J., Wentworth B. B. In vitro antibacterial activity of trospectomycin (U-63366F), a novel spectinomycin analog. Antimicrob Agents Chemother. 1988 Feb;32(2):216–223. doi: 10.1128/aac.32.2.216. [DOI] [PMC free article] [PubMed] [Google Scholar]