Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1991 Jul;35(7):1520–1523. doi: 10.1128/aac.35.7.1520

Inhibition of Cryptosporidium parvum in neonatal Hsd:(ICR)BR Swiss miceby polyether ionophores and aromatic amidines.

B L Blagburn 1, C A Sundermann 1, D S Lindsay 1, J E Hall 1, R R Tidwell 1
PMCID: PMC245207  PMID: 1929322

Abstract

Cryptosporidicidal effects of two polyether ionophores (maduramicin and alborixin), a fluorinated 4-quinolone (enrofloxacin), and three analogs of pentamidine were evaluated in a suckling mouse bioassay. Treatment with all compounds except enrofloxacin and one of the pentamidine analogs [1,3-di(4-imidazolinophenoxy)propane] resulted in significant (P less than 0.05) reductions in oocyst excretion.

Full text

PDF
1522

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bell C. A., Hall J. E., Kyle D. E., Grogl M., Ohemeng K. A., Allen M. A., Tidwell R. R. Structure-activity relationships of analogs of pentamidine against Plasmodium falciparum and Leishmania mexicana amazonensis. Antimicrob Agents Chemother. 1990 Jul;34(7):1381–1386. doi: 10.1128/aac.34.7.1381. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Dougherty T. J., Saukkonen J. J. Membrane permeability changes associated with DNA gyrase inhibitors in Escherichia coli. Antimicrob Agents Chemother. 1985 Aug;28(2):200–206. doi: 10.1128/aac.28.2.200. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Jones S. K., Hall J. E., Allen M. A., Morrison S. D., Ohemeng K. A., Reddy V. V., Geratz J. D., Tidwell R. R. Novel pentamidine analogs in the treatment of experimental Pneumocystis carinii pneumonia. Antimicrob Agents Chemother. 1990 Jun;34(6):1026–1030. doi: 10.1128/aac.34.6.1026. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. McDonald V., Stables R., Warhurst D. C., Barer M. R., Blewett D. A., Chapman H. D., Connolly G. M., Chiodini P. L., McAdam K. P. In vitro cultivation of Cryptosporidium parvum and screening for anticryptosporidial drugs. Antimicrob Agents Chemother. 1990 Aug;34(8):1498–1500. doi: 10.1128/aac.34.8.1498. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Moon H. W., Woode G. N., Ahrens F. A. Attempted chemoprophylaxis of cryptosporidiosis in calves. Vet Rec. 1982 Feb 20;110(8):181–181. doi: 10.1136/vr.110.8.181-a. [DOI] [PubMed] [Google Scholar]
  6. Rehg J. E., Hancock M. L., Woodmansee D. B. Characterization of cyclophosphamide-rat model of cryptosporidiosis. Infect Immun. 1987 Nov;55(11):2669–2674. doi: 10.1128/iai.55.11.2669-2674.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Sherwood D., Angus K. W., Snodgrass D. R., Tzipori S. Experimental cryptosporidiosis in laboratory mice. Infect Immun. 1982 Nov;38(2):471–475. doi: 10.1128/iai.38.2.471-475.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Soave R., Danner R. L., Honig C. L., Ma P., Hart C. C., Nash T., Roberts R. B. Cryptosporidiosis in homosexual men. Ann Intern Med. 1984 Apr;100(4):504–511. doi: 10.7326/0003-4819-100-4-504. [DOI] [PubMed] [Google Scholar]
  9. Tidwell R. R., Jones S. K., Geratz J. D., Ohemeng K. A., Cory M., Hall J. E. Analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia. J Med Chem. 1990 Apr;33(4):1252–1257. doi: 10.1021/jm00166a026. [DOI] [PubMed] [Google Scholar]
  10. Tzipori S. R., Campbell I., Angus K. W. The therapeutic effect of 16 antimicrobial agents on Cryptosporidium infection in mice. Aust J Exp Biol Med Sci. 1982 Apr;60(Pt 2):187–190. doi: 10.1038/icb.1982.20. [DOI] [PubMed] [Google Scholar]
  11. Upton S. J., Current W. L. The species of Cryptosporidium (Apicomplexa: Cryptosporidiidae) infecting mammals. J Parasitol. 1985 Oct;71(5):625–629. [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES