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. 1991 Aug;35(8):1688–1690. doi: 10.1128/aac.35.8.1688

Comparison of single-dose administration and three-day course of amoxicillin with those of clavulanic acid for treatment of uncomplicated urinary tract infection in women.

R Raz 1, E Rottensterich 1, S Boger 1, I Potasman 1
PMCID: PMC245246  PMID: 1929343

Abstract

In a double-blind randomized study we compared a single-dose amoxicillin-clavulanate combination with a regular 3-day regimen in 109 women with cystitis. Clinical cure rates at 7 and 28 days posttreatment were 78 versus 87% and 67 versus 78%, respectively. The 3-day regimen was significantly better (P less than 0.001) only in women with recurrent urinary tract infections.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abbas A. M., Chandra V., Dongaonkar P. P., Goel P. K., Kacker P., Patel N. A., Shrivastava O. P., Thakkar B., Tillotson G. S. Ciprofloxacin versus amoxycillin/clavulanic acid in the treatment of urinary tract infections in general practice. J Antimicrob Chemother. 1989 Aug;24(2):235–239. doi: 10.1093/jac/24.2.235. [DOI] [PubMed] [Google Scholar]
  2. Brogden R. N., Carmine A., Heel R. C., Morley P. A., Speight T. M., Avery G. S. Amoxycillin/clavulanic acid: a review of its antibacterial activity, pharmacokinetics and therapeutic use. Drugs. 1981 Nov;22(5):337–362. doi: 10.2165/00003495-198122050-00001. [DOI] [PubMed] [Google Scholar]
  3. Fang L. S., Tolkoff-Rubin N. E., Rubin R. H. Efficacy of single-dose and conventional amoxicillin therapy in urinary-tract infection localized by the antibody-coated bacteria technic. N Engl J Med. 1978 Feb 23;298(8):413–416. doi: 10.1056/NEJM197802232980802. [DOI] [PubMed] [Google Scholar]
  4. Goldstein F. W., Kitzis M. D., Acar J. F. Effect of clavulanic acid and amoxycillin formulation against beta-lactamase producing Gram-negative bacteria in urinary tract infections. J Antimicrob Chemother. 1979 Nov;5(6):705–709. doi: 10.1093/jac/5.6.705. [DOI] [PubMed] [Google Scholar]
  5. Kunin C. M. Duration of treatment of urinary tract infections. Am J Med. 1981 Nov;71(5):849–854. doi: 10.1016/0002-9343(81)90383-1. [DOI] [PubMed] [Google Scholar]
  6. Raz R., Rottensterich E., Hefter H., Kennes Y., Potasman I. Single-dose ciprofloxacin in the treatment of uncomplicated urinary tract infection in women. Eur J Clin Microbiol Infect Dis. 1989 Dec;8(12):1040–1042. doi: 10.1007/BF01975166. [DOI] [PubMed] [Google Scholar]
  7. Stamey T. A. Recurrent urinary tract infections in female patients: an overview of management and treatment. Rev Infect Dis. 1987 Mar-Apr;9 (Suppl 2):S195–S210. doi: 10.1093/clinids/9.supplement_2.s195. [DOI] [PubMed] [Google Scholar]
  8. Stamm W. E., Hooton T. M., Johnson J. R., Johnson C., Stapleton A., Roberts P. L., Moseley S. L., Fihn S. D. Urinary tract infections: from pathogenesis to treatment. J Infect Dis. 1989 Mar;159(3):400–406. doi: 10.1093/infdis/159.3.400. [DOI] [PubMed] [Google Scholar]
  9. Tolkoff-Rubin N. E., Weber D., Fang L. S., Kelly M., Wilkinson R., Rubin R. H. Single-dose therapy with trimethoprim-sulfamethoxazole for urinary tract infection in women. Rev Infect Dis. 1982 Mar-Apr;4(2):444–448. doi: 10.1093/clinids/4.2.444. [DOI] [PubMed] [Google Scholar]

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