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. 1975 Jun;122(3):931–942. doi: 10.1128/jb.122.3.931-942.1975

Relationship between chromosome replication and cell division in a thymineless mutant of Escherichia coli B/r.

P A Meacock, R H Pritchard
PMCID: PMC246144  PMID: 1097407

Abstract

The relationship between chromosome replication and cell division was investigated in a thymineless mutant of Escherichia coli B/r. Examination of the changes in average cell mass and DNA content of exponential cultures resulting from changes in the thymine concentration in the growth medium suggested that as the replication time (C) is increased there is a decrease in the period between termination of a round of replication and the subsequent cell division (D). Observations on the pattern of DNA synthesis during the division cycle were consistent with this relationship. Nevertheless, the kinetics of transition of exponential cultures moving between steady states of growth with differing replication velocities provided evidence to support the view that the time of cell division is determined by termination of rounds of replication under steady-state conditions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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