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. 1974 Jan;117(1):56–62. doi: 10.1128/jb.117.1.56-62.1974

Molecular Specificities of R Factor-Determined Beta-Lactamases: Correlation with Plasmid Compatibility

R W Hedges 1, Naomi Datta 1, Polyxeni Kontomichalou 1, J T Smith 1
PMCID: PMC246524  PMID: 4587613

Abstract

Beta (β)-lactamases determined by 29 ampicillin resistance plasmids could be divided into two types. One, TEM-type, was very uniform with respect to substrate specificity but heterogeneous in absolute levels of β-lactamase activity. The TEM-type β-lactamase was determined by R factors of compatibility groups FII, Iα, Iε, N, C, A, T, W, P, L, and X, and by prophage φ Amp. The other type, characterized by the ability to hydrolyze oxacillin, was less common, showed lower absolute levels of activity, and was heterogeneous as regards substrate specificities. Oxacillin-hydrolyzing β-lactamases were determined by R factors of compatibility groups FI, Iα, N, C, and O.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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