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. 1969 Sep;45(527):602–607. doi: 10.1136/pgmj.45.527.602

The effect of dietary sucrose on blood lipids, serum insulin, platelet adhesiveness and body weight in human volunteers

Stephen Szanto, John Yudkin
PMCID: PMC2466139  PMID: 5809554

Abstract

A study was made of the effect of high or low intake of sucrose for periods of 14 days in a group of nineteen apparently healthy men.

The high sucrose diet produced no change in blood levels of cholesterol or phospholipids, or in glucose tolerance, but it produced a significant rise in triglycerides in all nineteen men. In six of them, there was in addition a rise in serum immunoreactive insulin, especially during the glucose tolerance test, and these same six subjects also showed a considerable increase in weight and a significant increase in platelet adhesiveness.

There was no difference between the six subjects and the remaining thirteen in any of the other measurements, or in the diets they consumed during the experiment. The changes produced by sucrose had disappeared, or nearly so, after 14 days of normal diet.

It is suggested that the effect of sucrose in producing hyperinsulinism may be more relevant to its possible role in the aetiology of ischaemic heart disease than its effect on blood lipids. It is further suggested that only some individuals are susceptible to the development of ischaemic heart disease by dietary sucrose, and that these may be identified as those that show ‘sucrose-induced hyperinsulinism’.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Akinyanju P. A., Qureshi R. U., Salter A. J., Yudkin J. Effect of an "atherogenic" diet containing starch or sucrose on the blood lipids of young men. Nature. 1968 Jun 8;218(5145):975–977. doi: 10.1038/218975a0. [DOI] [PubMed] [Google Scholar]
  2. BARTLETT G. R. Phosphorus assay in column chromatography. J Biol Chem. 1959 Mar;234(3):466–468. [PubMed] [Google Scholar]
  3. Cohen A. M., Teitelbaum A., Balogh M., Groen J. J. Effect of interchanging bread and sucrose as main source of carbohydrate in a low fat diet on the glucose tolerance curve of healthy volunteer subjects. Am J Clin Nutr. 1966 Jul;19(1):59–62. doi: 10.1093/ajcn/19.1.59. [DOI] [PubMed] [Google Scholar]
  4. DEVLIN J. G. THE EFFECT OF TRAINING AND ACUTE PHYSICAL EXERCISE ON PLASMA INSULIN-LIKE ACTIVITY. Ir J Med Sci. 1963 Sep;453:423–425. doi: 10.1007/BF02951610. [DOI] [PubMed] [Google Scholar]
  5. FEARNLEY G. R., BALMFORTH G., FEARNLEY E. Evidence of a diurnal fibrinolytic rhythm; with a simple method of measuring natural fibrinolysis. Clin Sci. 1957 Nov;16(4):645–650. [PubMed] [Google Scholar]
  6. GRODSKY G. M., KARAM J. H., PAVLATOS F. C., FORSHAM P. H. SERUM-INSULIN RESPONSE TO GLUCOSE IN PREDIABETIC SUBJECTS. Lancet. 1965 Feb 6;1(7380):290–291. doi: 10.1016/s0140-6736(65)91027-5. [DOI] [PubMed] [Google Scholar]
  7. HALES C. N., RANDLE P. J. Immunoassay of insulin with insulin-antibody precipitate. Biochem J. 1963 Jul;88:137–146. doi: 10.1042/bj0880137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. HUGGETT A. S., NIXON D. A. Use of glucose oxidase, peroxidase, and O-dianisidine in determination of blood and urinary glucose. Lancet. 1957 Aug 24;273(6991):368–370. doi: 10.1016/s0140-6736(57)92595-3. [DOI] [PubMed] [Google Scholar]
  9. Härtel G., Punsar S., Louhija A. Insulin and atherosclerosis. Lancet. 1968 Oct 26;2(7574):920–920. doi: 10.1016/s0140-6736(68)91098-2. [DOI] [PubMed] [Google Scholar]
  10. INGRAM G. I. A suggested schedule for the rapid investigation of acute haemostatic failure. J Clin Pathol. 1961 Jul;14:356–360. doi: 10.1136/jcp.14.4.356. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Joffe B. I., Bank S., Jackson W. P., Keller P., O'Reilly I. G., Vinik A. I. Insulin reserve in patients with chronic pancreatitis. Lancet. 1968 Oct 26;2(7574):890–892. doi: 10.1016/s0140-6736(68)91055-6. [DOI] [PubMed] [Google Scholar]
  12. Kingsbury K. J., Jarrett R. J. Effects of adrenaline and of smoking in patients with peripheral atherosclerotic vascular disease. Lancet. 1967 Jul 1;2(7505):22–23. doi: 10.1016/s0140-6736(67)90061-x. [DOI] [PubMed] [Google Scholar]
  13. MACDONALD L., BRAITHWAITE D. M. THE INFLUENCE OF DIETARY CARBOHYDRATES ON THE LIPID PATTERN IN SERUM AND IN ADIPOSE TISSUE. Clin Sci. 1964 Aug;27:23–30. [PubMed] [Google Scholar]
  14. Nikkilä E. A., Miettinen T. A., Vesenne M. R., Pelkonen R. Plasma-insulin in coronary heart-disease: response to oral and intravenous glucose and to tolbutamide. Lancet. 1965 Sep 11;2(7411):508–511. doi: 10.1016/s0140-6736(65)91471-6. [DOI] [PubMed] [Google Scholar]
  15. RABINOWITZ D., ZIERLER K. L. Role of free fatty acids in forearm metabolism in man, quantitated by use of insulin. J Clin Invest. 1962 Dec;41:2191–2197. doi: 10.1172/JCI104678. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. SAMAAN N., BROWN J., FRASER R., TRAYNER I. EFFECT OF OBESITY AND OF STARVATION ON INSULIN ACTIVITY. Br Med J. 1965 May 1;1(5443):1153–1156. doi: 10.1136/bmj.1.5443.1153. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Stout R. W. Insulin-stimulated lipogenesis in arterial tissue in relation to diabetes and atheroma. Lancet. 1968 Sep 28;2(7570):702–703. doi: 10.1016/s0140-6736(68)90748-4. [DOI] [PubMed] [Google Scholar]
  18. Szanto S. Smoking and atherosclerosis. Br Med J. 1967 Jul 15;3(5558):178–178. doi: 10.1136/bmj.3.5558.178-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. VALLANCE-OWEN J., ASHTON W. L. Cardiac infarction and insulin antagonism. Lancet. 1963 Jun 8;1(7293):1226–1228. doi: 10.1016/s0140-6736(63)91860-9. [DOI] [PubMed] [Google Scholar]
  20. VAN HANDEL E., ZILVERSMIT D. B. Micromethod for the direct determination of serum triglycerides. J Lab Clin Med. 1957 Jul;50(1):152–157. [PubMed] [Google Scholar]
  21. Welborn T. A., Breckenridge A., Rubinstein A. H., Dollery C. T., Fraser T. R. Serum-insulin in essential hypertension and in peripheral vascular disease. Lancet. 1966 Jun 18;1(7451):1336–1337. doi: 10.1016/s0140-6736(66)92132-5. [DOI] [PubMed] [Google Scholar]
  22. YALOW R. S., BERSON S. A. Plasma insulin concentrations in nondiabetic and early diabetic subjects. Determinations by a new sensitive immuno-assay technic. Diabetes. 1960 Jul-Aug;9:254–260. doi: 10.2337/diab.9.4.254. [DOI] [PubMed] [Google Scholar]
  23. YUDKIN J. PATTERNS AND TRENDS IN CARBOHYDRATE CONSUMPTION AND THEIR RELATION TO DISEASE. Proc Nutr Soc. 1964;23:149–162. doi: 10.1079/pns19640028. [DOI] [PubMed] [Google Scholar]
  24. Yudkin J., Kakkar V. V., Szanto S. Sugar intake, serum insulin and platelet adhesiveness in men with and without peripheral vascular disease. Postgrad Med J. 1969 Sep;45(527):608–611. doi: 10.1136/pgmj.45.527.608. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Yudkin J. Why blame sugar? Chem Ind. 1967 Sep 2;35:1464–1466. [PubMed] [Google Scholar]
  26. ZLATKIS A., ZAK B., BOYLE A. J. A new method for the direct determination of serum cholesterol. J Lab Clin Med. 1953 Mar;41(3):486–492. [PubMed] [Google Scholar]

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