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. 1974 Apr;118(1):41–45. doi: 10.1128/jb.118.1.41-45.1974

Biosynthesis of Ubiquinone in Escherichia coli K-12: Biochemical and Genetic Characterization of a Mutant Unable to Convert Chorismate into 4-Hydroxybenzoate

J Lawrence 1, G B Cox 1, F Gibson 1
PMCID: PMC246637  PMID: 4595202

Abstract

A mutant strain of Escherichia coli unable to carry out the first specific reaction of ubiquinone biosynthesis, that is the conversion of chorismate into 4-hydroxybenzoate, has been isolated. The gene concerned maps at about minute 79 on the E. coli chromosome and has been designated ubiC. This gene is probably the structural gene for chorismate lyase since cell extracts from a transductant strain carrying the ubiC437 mutant allele are unable to convert chorismate into 4-hydroxybenzoate and growing cells of the mutant do not form appreciable quantities of ubiquinone unless 4-hydroxybenzoate is added to the growth medium.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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