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. 1971 Sep;107(3):741–745. doi: 10.1128/jb.107.3.741-745.1971

Isoleucine Hydroxamate, an Isoleucine Antagonist

Masahiko Kisumi 1, Saburo Komatsubara 1, Masaki Sugiura 1, Ichiro Chibata 1
PMCID: PMC246995  PMID: 4937785

Abstract

Isoleucine hydroxamate (Ile·Hdx) was found to inhibit the growth of Serratia marcescens and to antagonize isoleucine. At a low concentration of Ile·Hdx, at which the growth of the wild strain was completely inhibited, the growth of an isoleucine auxotroph was not inhibited in the medium containing a limiting amount of d-threonine as the isoleucine source. At a higher concentration, this antagonist exhibited a considerable inhibitory effect on the growth of the auxotroph. Ile·Hdx showed the same inhibitory effect as isoleucine on l-threonine dehydratase activity at the concentrations 10 times those of isoleucine. Ile·Hdx caused also derepression of isoleucine-valine biosynthetic enzymes and the derepression was overcome by isoleucine. These results indicate the Ile·Hdx causes growth inhibition by its effects on isoleucine metabolism.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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