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. 1971 Oct;108(1):74–81. doi: 10.1128/jb.108.1.74-81.1971

Nucleoside Triphosphate Pools in Synchronous Cultures of Escherichia coli1

Lydia Huzyk a, D Joseph Clark a
PMCID: PMC247034  PMID: 4941576

Abstract

Endogenous nucleoside triphosphate pools in synchronized cultures of Escherichia coli B/r/1 oscillate as a function of age. Purine nucleoside triphosphates show a gradual 50% increase from zero age to the time of subsequent division, immediately prior to division. In contrast, pyrimidine nucleoside triphosphates undergo a dramatic change of about 50% in the first half of the generation at a time coincident with the termination of a round of deoxyribonucleic acid replication. A 50 to 70% increase starts at the initiation of the next round of deoxyribonucleic acid replication and continues until cell division, in parallel with the purine nucleotides. The fluctuation of pyrimidines between zero age and the middle of the division cycle suggests a functional relationship for pyrimidine metabolism and the regulation of cell division.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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