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. 1972 Mar;109(3):993–1000. doi: 10.1128/jb.109.3.993-1000.1972

The pi-Histidine Factor of Salmonella typhimurium: a Demonstration that pi-Histidine Factor Integrates into the Chromosome

Mark Levinthal a, Jen Yeh a,1
PMCID: PMC247319  PMID: 4551760

Abstract

The Salmonella typhimurium pi-histidine episome was identified by Ames et al. (2) in an unstable partial revertant of a deletion mutation-containing strain, hisG203. HisG203 lacks the histidine operator, promoter, and part of the first structural gene. In this paper, we study some properties of pi factor and demonstrate a low frequency of pi integration into the chromosome at or near the histidine region.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AMES B. N., HARTMAN P. E., JACOB F. Chromosomal alterations affecting the regulation of histidine biosynthetic enzymes in Salmonella. J Mol Biol. 1963 Jul;7:23–42. doi: 10.1016/s0022-2836(63)80016-9. [DOI] [PubMed] [Google Scholar]
  2. Atkins J. F., Loper J. C. Transcription initiation in the histidine operon of Salmonella typhimurium. Proc Natl Acad Sci U S A. 1970 Apr;65(4):925–932. doi: 10.1073/pnas.65.4.925. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. FRAENKEL D. G., HORECKER B. L. PATHWAYS OF D-GLUCOSE METABOLISM IN SALMONELLA TYPHINMURIUM. A STUDY OF A MUTANT LACKING PHOSPHOGLUCOSE ISOMERASE. J Biol Chem. 1964 Sep;239:2765–2771. [PubMed] [Google Scholar]
  4. Fink G. R., Klopotowski T., Ames B. N. Histidine regulatory mutants in Salmonella typhimurium. IV. A positive selection for polar histidine-requiring mutants from histidine operator constitutive mutants. J Mol Biol. 1967 Nov 28;30(1):81–95. doi: 10.1016/0022-2836(67)90245-8. [DOI] [PubMed] [Google Scholar]
  5. Fink G. R., Martin R. G. Translation and polarity in the histidine operon. II. Polarity in the histidine operon. J Mol Biol. 1967 Nov 28;30(1):97–107. doi: 10.1016/0022-2836(67)90246-x. [DOI] [PubMed] [Google Scholar]
  6. Grabner M., Hartman P. E. MG40 phage, a transducing phage related to P22. Virology. 1968 Mar;34(3):521–530. doi: 10.1016/0042-6822(68)90071-8. [DOI] [PubMed] [Google Scholar]
  7. Murray M. L., Klopotowski T. Genetic map position of the gluconate-6-phosphate dehydrogenase gene in Salmonella typhimurium. J Bacteriol. 1968 Apr;95(4):1279–1282. doi: 10.1128/jb.95.4.1279-1282.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Peyru G., Fraenkel D. G. Genetic mapping of loci for glucose-6-phosphate dehydrogenase, gluconate-6-phosphate dehydrogenase, and gluconate-6-phosphate dehydrase in Escherichia coli. J Bacteriol. 1968 Apr;95(4):1272–1278. doi: 10.1128/jb.95.4.1272-1278.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. SMITH D. W., AMES B. N. INTERMEDIATES IN THE EARLY STEPS OF HISTIDINE BIOSYNTHESIS. J Biol Chem. 1964 Jun;239:1848–1855. [PubMed] [Google Scholar]
  10. Sanderson K. E. Current linkage map of Salmonella typhimurium. Bacteriol Rev. 1970 Jun;34(2):176–193. doi: 10.1128/br.34.2.176-193.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Scaife J. F-prime factor formation in E. coli K12. Genet Res. 1966 Oct;8(2):189–196. doi: 10.1017/s0016672300010041. [DOI] [PubMed] [Google Scholar]
  12. Signer E. R. Lysogeny: the integration problem. Annu Rev Microbiol. 1968;22:451–488. doi: 10.1146/annurev.mi.22.100168.002315. [DOI] [PubMed] [Google Scholar]
  13. Smith H. O., Levine M. A phage P22 gene controlling integration of prophage. Virology. 1967 Feb;31(2):207–216. doi: 10.1016/0042-6822(67)90164-x. [DOI] [PubMed] [Google Scholar]
  14. St Pierre M. L. Mutations creating a new initiation point for expression of the histidine operon in Salmonella typhimurium. J Mol Biol. 1968 Jul 14;35(1):71–82. doi: 10.1016/s0022-2836(68)80037-3. [DOI] [PubMed] [Google Scholar]
  15. VOGEL H. J., BONNER D. M. Acetylornithinase of Escherichia coli: partial purification and some properties. J Biol Chem. 1956 Jan;218(1):97–106. [PubMed] [Google Scholar]

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