Abstract
The deficiencies of the drugs used for the treatment of bilharziasis have limited attempts at control of the disease by chemotherapy. The present paper records a series of field trials with a new, orally administered, non-metallic schistosomicide, Ambilhar, in schoolchildren in an area of endemic urinary bilharziasis in Tanzania. The results indicate that the compound represents an important advance in the chemotherapy of Schistosoma haematobium infections. High cure rates and marked reduction of egg excretion in those not cured reveal prospects of wider population coverage by drug treatment of schoolchildren, the age-group most at risk and most in need of treatment.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Davis A. Effect of Ciba 32644-Ba on Schistosoma haematobium. Acta Trop Suppl. 1966;9:132–144. [PubMed] [Google Scholar]
- FORSYTH D. M., BRADLEY D. J. IRREVERSIBLE DAMAGE BY SCHISTOSOMA HAEMATOBIUM IN SCHOOLCHILDREN. Lancet. 1964 Jul 25;2(7352):169–171. doi: 10.1016/s0140-6736(64)90230-2. [DOI] [PubMed] [Google Scholar]
- LAMBERT C. R. CHEMOTHERAPY OF EXPERIMENTAL SCHISTOSOMA MANSONI INFECTIONS WITH A NITRO-THIAZOLE DERIVATIVE, CIBA 32,644-BA. Ann Trop Med Parasitol. 1964 Sep;58:292–303. doi: 10.1080/00034983.1964.11686246. [DOI] [PubMed] [Google Scholar]
- Pesigan T. P., Banzon T. C., Zabala R. G. Treatment of Schistosomiasis japonica with Ciba 32644-Ba. A prliminary report. Acta Trop Suppl. 1966;9:224–235. [PubMed] [Google Scholar]
- Powell S. J., MacLeod I., Wilmot A. J., Elsdon-Dew R. Ambilhar in amoebic dysentery and amoebic liver abscess. Lancet. 1966 Jul 2;2(7453):20–22. doi: 10.1016/s0140-6736(66)91747-8. [DOI] [PubMed] [Google Scholar]
- Wolfe H. L. Treatment of urinary schistosomiasis with niridazole (Ambilhar) in 576 African schoolchildren. Lancet. 1967 Feb 18;1(7486):350–354. doi: 10.1016/s0140-6736(67)92894-2. [DOI] [PubMed] [Google Scholar]