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. 1989 Feb;63(2):987–991. doi: 10.1128/jvi.63.2.987-991.1989

Phosphorylation at serine 89 induces a shift in gel mobility but has little effect on the function of adenovirus type 5 E1A proteins.

D J Dumont 1, M L Tremblay 1, P E Branton 1
PMCID: PMC247781  PMID: 2536123

Abstract

Phosphorylation at serine 89 was shown to be the major cause of the shift in gel migration of the 289R and 243R early region 1A (E1A) proteins of human adenovirus type 5. However, conversion of Ser-89 to alanine by site-directed mutagenesis did not abolish E1A transactivating or transforming activities, suggesting that phosphorylation at this site is not necessary for these E1A functions.

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Selected References

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