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. 1989 Mar;63(3):1408–1412. doi: 10.1128/jvi.63.3.1408-1412.1989

Amino acid sequence of a conserved neutralizing epitope of murine coronaviruses.

W Luytjes 1, D Geerts 1, W Posthumus 1, R Meloen 1, W Spaan 1
PMCID: PMC247841  PMID: 2464703

Abstract

We identified the binding site of monoclonal antibody 19.2, which cross-neutralizes several mouse hepatitis virus (MHV) strains, inhibits fusion of MHV-infected cells, and protects against lethal infection (P. J. Talbot and M. J. Buchmeier, Virus Res. 2:317-328, 1985). We used fusion proteins, generated by expression of fragments of the MHV A59 E2 gene in pEX plasmids, and synthetic peptides in a PEPSCAN.

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Selected References

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