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. 1990 Sep;64(9):4549–4552. doi: 10.1128/jvi.64.9.4549-4552.1990

Epstein-Barr virus BZLF1 trans activator induces the promoter of a cellular cognate gene, c-fos.

E Flemington 1, S H Speck 1
PMCID: PMC247926  PMID: 2166830

Abstract

The Epstein-Barr virus BZLF1 gene product ZEBRA is a DNA-binding protein that is partially homologous to c-Fos, binds specifically to AP-1 sites, and can induce the lytic cycle in latently infected B lymphocytes. Induction of the viral lytic cycle can also be achieved by treatment with the phorbol ester 12-O-tetrade-canoylphorbol-13-acetate, a reagent which activates gene expression in part through AP-1 (Jun/Fos). In this article the interrelationship between ZEBRA and AP-1 is extended by the demonstration that ZEBRA can induce c-Fos expression through AP-1 and "AP-1-like" sites present in the c-fos promoter. Induction of c-Fos may be necessary for the expression of other viral lytic genes and perhaps cellular genes whose products are required for viral replication.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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