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Bulletin of the World Health Organization logoLink to Bulletin of the World Health Organization
. 1972;47(5):611–618.

Rodent resistance to the anticoagulant rodenticides, with particular reference to Denmark

M Lund
PMCID: PMC2480843  PMID: 4540680

Abstract

Inherited resistance to anticoagulant rodenticides was discovered in populations of Rattus norvegicus about 14 years ago. Similar resistance has now been reported from several countries in north-western Europe and from the USA. In order to detect resistance and to control it effectively, basic data on the susceptibility of rat populations are required for each country, and trapping surveys should be made in any area where resistance is suspected. Acute poisons are needed to control resistant rats although the shift from anticoagulants to acute poisons is a retrograde step as far as efficiency is concerned, and increases the hazard of control operations to man and other animals. Resistance to anticoagulants in Mus musculus has been reported from England, and resistant mice are probably to be found in other countries also in view of the great individual variation in susceptibility of this species to these rodenticides.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Drummond D. C., Wilson E. J. Laboratory investigations of resistance to warfarin of Rattus norvegicus Berk. In Montgome norvegicus Berk. in Montgomeryshire and Shropshire. Ann Appl Biol. 1968 Apr;61(2):303–312. doi: 10.1111/j.1744-7348.1968.tb04535.x. [DOI] [PubMed] [Google Scholar]
  2. Greaves J. H., Ayres P. Linkages between genes for coat colour and resistance to warfarin in Rattus norvegicus. Nature. 1969 Oct 18;224(5216):284–285. doi: 10.1038/224284a0. [DOI] [PubMed] [Google Scholar]
  3. Greaves J. H., Ayres P. Some rodenticidal properties of coumatetralyl. J Hyg (Lond) 1969 Jun;67(2):311–315. doi: 10.1017/s0022172400041711. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Greavses J. H., Ayres P. Heritable resistance to warfarin in rats. Nature. 1967 Aug 19;215(5103):877–878. doi: 10.1038/215877a0. [DOI] [PubMed] [Google Scholar]
  5. Hermodson M. A., Suttie J. W., Link K. P. Warfarin metabolism and vitamin K requirement in the warfarin-resistant rat. Am J Physiol. 1969 Nov;217(5):1316–1319. doi: 10.1152/ajplegacy.1969.217.5.1316. [DOI] [PubMed] [Google Scholar]
  6. Jackson W. B., Kaukeinen D. Resistance of wild Norway rats in North Carolina to warfarin rodenticide. Science. 1972 Jun 23;176(4041):1343–1344. doi: 10.1126/science.176.4041.1343. [DOI] [PubMed] [Google Scholar]
  7. LUND M. RESISTANCE TO WARFARIN IN THE COMMON RAT. Nature. 1964 Aug 15;203:778–778. doi: 10.1038/203778a0. [DOI] [PubMed] [Google Scholar]
  8. Pool J. G., O'Reilly R. A., Schneiderman L. J., Alexander M. Warfarin resistance in the rat. Am J Physiol. 1968 Sep;215(3):627–631. doi: 10.1152/ajplegacy.1968.215.3.627. [DOI] [PubMed] [Google Scholar]
  9. ROWE F. P., REDFERN R. THE TOXICITY OF 0-025 PER CENT WARFARIN TO WILD HOUSE-MICE (MUS MUSCULUS L.). J Hyg (Lond) 1964 Sep;62:389–393. doi: 10.1017/s0022172400040109. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Rowe F. P., Redfern R. Laboratory studies on the toxicity of anti-coagulant rodenticides to wild house-mice (Mus musculus L.). Ann Appl Biol. 1968 Apr;61(2):322–326. [PubMed] [Google Scholar]
  11. Rowe F. P., Redfern R. Toxicity tests on suspected warfarin resistant house mice (Mus musculus L.). J Hyg (Lond) 1965 Sep;63(3):417–425. doi: 10.1017/s0022172400045307. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Webb R. E., Horsfall F., Jr Endrin resistance in the pine mouse. Science. 1967 Jun 30;156(3783):1762–1762. doi: 10.1126/science.156.3783.1762-a. [DOI] [PubMed] [Google Scholar]

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