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. 1974;50(3-4):251–257.

Mechanisms of immunity to malaria*

S Cohen, G A Butcher, G H Mitchell
PMCID: PMC2481208  PMID: 4548392

Abstract

The erythrocytic phase of malarial infection provides a potent stimulus for the production of specific malarial antibody. Serologic tests do not provide any indication of immune status, so that much specific antibody has no protective function. The role of serum antibody in acquired malarial immunity has, however, been established by passive transfer tests, and in the case of P. knowlesi by specific inhibition of the cyclic growth of parasites in vitro. The inhibitory antibody appears to combine with merozoites and prevents their attachment to red cells, thus interrupting the cyclic proliferation of the parasite. The inhibitory antibody response is predominantly variant-specific, but cross-reacting antibody occurs in sufficient amount to suppress proliferation of most other variants of the species. The occurrence of cross-immunity between variants is encouraging from the point of view of vaccination. If it were possible to isolate cross-reacting antigens, these could provide the basis for a malarial vaccine effective against erythrocytic forms of the parasite.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown I. N., Allison A. C., Taylor R. B. Plasmodium berghei infections in thymectomized rats. Nature. 1968 Jul 20;219(5151):292–293. doi: 10.1038/219292a0. [DOI] [PubMed] [Google Scholar]
  2. Brown I. N. Immunological aspects of malaria infection. Adv Immunol. 1969;11:267–349. doi: 10.1016/s0065-2776(08)60481-2. [DOI] [PubMed] [Google Scholar]
  3. Brown K. N. Antibody induced variation in malaria parasites. Nature. 1973 Mar 2;242(5392):49–50. doi: 10.1038/242049a0. [DOI] [PubMed] [Google Scholar]
  4. Brown K. N., Brown I. N. Immunity to malaria: antigenic variation in chronic infections of Plasmodium knowlesi. Nature. 1965 Dec 25;208(5017):1286–1288. doi: 10.1038/2081286a0. [DOI] [PubMed] [Google Scholar]
  5. Butcher G. A., Cohen S. Antigenic variation and protective immunity in Plasmodium knowlesi malaria. Immunology. 1972 Oct;23(4):503–521. [PMC free article] [PubMed] [Google Scholar]
  6. Butcher G., Cohen S. Schizogony of Plasmodium knowlesi in the presence of normal and immune sera. Trans R Soc Trop Med Hyg. 1970;64(4):470–470. doi: 10.1016/0035-9203(70)90041-6. [DOI] [PubMed] [Google Scholar]
  7. COHEN S., McGREGOR I. A., CARRINGTON S. Gamma-globulin and acquired immunity to human malaria. Nature. 1961 Nov 25;192:733–737. doi: 10.1038/192733a0. [DOI] [PubMed] [Google Scholar]
  8. Cohen S., Butcher G. A., Crandall R. B. Action of malarial antibody in vitro. Nature. 1969 Jul 26;223(5204):368–371. doi: 10.1038/223368a0. [DOI] [PubMed] [Google Scholar]
  9. Cohen S., Butcher G. A. Properties of protective malarial antibody. Immunology. 1970 Aug;19(2):369–383. [PMC free article] [PubMed] [Google Scholar]
  10. Eaton M. D. THE AGGLUTINATION OF PLASMODIUM KNOWLESI BY IMMUNE SERUM. J Exp Med. 1938 May 31;67(6):857–870. doi: 10.1084/jem.67.6.857. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Phillips R. S. Plasmodium berghei: passive transfer of immunity by antisera and cells. Exp Parasitol. 1970 Jun;27(3):479–495. doi: 10.1016/0014-4894(70)90052-4. [DOI] [PubMed] [Google Scholar]
  12. Rowe D. S., McGregor I. A., Smith S. J., Hall P., Williams K. Plasma immunoglobulin concentrations in a West African (Gambian) community and in a group of healthy British adults. Clin Exp Immunol. 1968 Jan;3(1):63–79. [PMC free article] [PubMed] [Google Scholar]
  13. Spira D. T., Silverman P. H., Gaines C. Anti-thymocyte serum effects on Plasmodium berghei infection in rats. Immunology. 1970 Nov;19(5):759–766. [PMC free article] [PubMed] [Google Scholar]
  14. Stechschulte D. J. Cell-mediated immunity in rats infected with Plasmodium berghei. Mil Med. 1969 Sep;134(10):1147–1152. [PubMed] [Google Scholar]
  15. Voller A., Rossan R. N. Immunological studies on simian malaria. 3. Immunity to challenge and antigenic variation in P. knowlesi. Trans R Soc Trop Med Hyg. 1969;63(4):507–523. [PubMed] [Google Scholar]

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