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. 1989 Apr;63(4):1737–1742. doi: 10.1128/jvi.63.4.1737-1742.1989

Distinct factors bind the AP-1 consensus sites in gibbon ape leukemia virus and simian virus 40 enhancers.

J P Quinn 1, M Takimoto 1, M Iadarola 1, N Holbrook 1, D Levens 1
PMCID: PMC248435  PMID: 2538654

Abstract

We have demonstrated that the gibbon ape leukemia virus (GALV) enhancer AP-1 element and the simian virus 40 AP-1 enhancer element bind different factors in HeLa nuclear extracts. A 39-kilodalton HeLa nuclear protein and the c-fos protein bind to the GALV element. Antibodies to c-fos abolish binding to the GALV AP-1 site. In contrast, anti-c-fos immunoglobulin fails to inhibit formation of the simian virus 40-specific complex from extracts of HeLa cells. Thus, AP-1-binding complexes are subject to compositional variation at different binding sites.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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