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. 1971 Apr;106(1):221–226. doi: 10.1128/jb.106.1.221-226.1971

Mechanism of Inactivation of Transforming Deoxyribonucleic Acid by X Rays

M L Randolph 1, Jane K Setlow 1
PMCID: PMC248665  PMID: 5313645

Abstract

Transforming deoxyribonucleic acid (DNA) from Haemophilus influenzae was exposed to X rays either in phosphate buffer or in 10% yeast extract. Relations between determinations of biological inactivation, DNA uptake by competent H. influenzae, integration of DNA into the competent cell genome, and induced single-and double-strand breaks indicate that transforming DNA is inactivated by the direct and the indirect effect of X radiation primarily because integration of DNA is prevented as a result of the production of double-strand breaks.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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