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. 1994;72(6):921–930.

Malaria control and longitudinal changes in levels of DDT and its metabolites in human serum from KwaZulu.

H Bouwman 1, P J Becker 1, C H Schutte 1
PMCID: PMC2486741  PMID: 7867138

Abstract

Blood samples were obtained on four occasions over a 12-month period from individuals living in KwaZulu, South Africa, who had been exposed to DDT (1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane) as a consequence of its use in their homes to control transmission of malaria. The longitudinal changes in serum DDT and its major metabolities, DDE and DDD, were determined. No additional risk was considered to have been presented by the increases that occurred following application of the pesticide. There were significant increases in DDT, DDE and sigma DDT (DDT + its metabolites) for the age group > or = 21 years, but for the age group 3-20 years a reduction in serum levels occurred over 12 months. Two concurrent processes probably govern the increase and decrease in serum levels, and the relative contributions of each interchange as the individual becomes older. The results suggest that children in KwaZulu experience conditions that differ from those of their parents, as well as from those that affect children in developed countries. In consequence, it is desirable that risk assessments of vector control chemicals consider all sectors of a population.

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Selected References

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  1. Agarwal H. C., Pillai M. K., Yadav D. V., Menon K. B., Gupta R. K. Residues of DDT and its metabolites in human blood samples in Delhi, India. Bull World Health Organ. 1976;54(3):349–351. [PMC free article] [PubMed] [Google Scholar]
  2. Austin H., Keil J. E., Cole P. A prospective follow-up study of cancer mortality in relation to serum DDT. Am J Public Health. 1989 Jan;79(1):43–46. doi: 10.2105/ajph.79.1.43. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bouwman H., Becker P. J., Cooppan R. M., Reinecke A. J. Transfer of DDT used in malaria control to infants via breast milk. Bull World Health Organ. 1992;70(2):241–250. [PMC free article] [PubMed] [Google Scholar]
  4. Bouwman H., Cooppan R. M., Becker P. J., Ngxongo S. Malaria control and levels of DDT in serum of two populations in Kwazulu. J Toxicol Environ Health. 1991 Jun;33(2):141–155. doi: 10.1080/15287399109531514. [DOI] [PubMed] [Google Scholar]
  5. Bouwman H., Cooppan R. M., Reinecke A. J., Becker P. J. Levels of DDT and metabolites in breast milk from Kwa-Zulu mothers after DDT application for malaria control. Bull World Health Organ. 1990;68(6):761–768. [PMC free article] [PubMed] [Google Scholar]
  6. Bouwman H., Reinecke A. J., Cooppan R. M., Becker P. J. Factors affecting levels of DDT and metabolites in human breast milk from Kwazulu. J Toxicol Environ Health. 1990 Oct;31(2):93–115. doi: 10.1080/15287399009531440. [DOI] [PubMed] [Google Scholar]
  7. Brown J. R., Chow L. Y. Comparative study of DDT and its derivatives in human blood samples in Norfolk County and Holland Marsh, Ontario. Bull Environ Contam Toxicol. 1975 Apr;13(4):483–488. doi: 10.1007/BF01721856. [DOI] [PubMed] [Google Scholar]
  8. Davies J. E., Edmundson W. F., Maceo A., Barquet A., Cassady J. An epidemiologic application of the study of DDE levels in whole blood. Am J Public Health Nations Health. 1969 Mar;59(3):435–441. doi: 10.2105/ajph.59.3.435. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Laws E. R., Jr, Curley A., Biros F. J. Men with intensive occupational exposure to DDT. A clinical and chemical study. Arch Environ Health. 1967 Dec;15(6):766–775. doi: 10.1080/00039896.1967.10664995. [DOI] [PubMed] [Google Scholar]
  10. Laws E. R., Jr, Maddrey W. C., Curley A., Burse V. W. Long-term occupational exposure to DDT. Arch Environ Health. 1973 Nov;27(5):318–321. doi: 10.1080/00039896.1973.10666387. [DOI] [PubMed] [Google Scholar]
  11. Morgan D. P., Roan C. C. Absorption, storage, and metabolic conversion of ingested DDT and DDT metabolites in man. Arch Environ Health. 1971 Mar;22(3):301–308. doi: 10.1080/00039896.1971.10665848. [DOI] [PubMed] [Google Scholar]
  12. Morgan D. P., Roan C. C. Liver function in workers having high tissue stores of chlorinated hydrocarbon pesticides. Arch Environ Health. 1974 Jul;29(1):14–17. doi: 10.1080/00039896.1974.10666519. [DOI] [PubMed] [Google Scholar]
  13. Mpofu S. M., Mpoful M. Human levels of DDT residues in selected Zimbabwe communities. Cent Afr J Med. 1986 Dec;32(12):285–289. [PubMed] [Google Scholar]
  14. Murphy R., Harvey C. Residues and metabolites of selected persistent halogenated hydrocarbons in blood specimens from a general population survey. Environ Health Perspect. 1985 May;60:115–120. doi: 10.1289/ehp.8560115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Perron R. C., Barrentine B. F. Human serum DDT concentration related to environmental DDT exposure. Arch Environ Health. 1970 Mar;20(3):368–376. doi: 10.1080/00039896.1970.10665606. [DOI] [PubMed] [Google Scholar]
  16. Pines A., Cucos S., Ever-Hadani P., Ron M., Lemesch C. Changes in pattern of organochlorine residues in blood of general Israeli population, 1975-1986. Sci Total Environ. 1987 Oct;66:115–125. doi: 10.1016/0048-9697(87)90081-7. [DOI] [PubMed] [Google Scholar]
  17. Poland A., Smith D., Kuntzman R., Jacobson M., Conney A. H. Effect of intensive occupational exposure to DDT on phenylbutazone and cortisol metabolism in human subjects. Clin Pharmacol Ther. 1970 Sep-Oct;11(5):724–732. doi: 10.1002/cpt1970115724. [DOI] [PubMed] [Google Scholar]
  18. Radomski J. L., Astolfi E., Deichmann W. B., Rey A. A. Blood levels of organochlorine pesticides in Argentina: occupationally and nonoccupationally exposed adults, children and newborn infants. Toxicol Appl Pharmacol. 1971 Oct;20(2):186–193. doi: 10.1016/0041-008x(71)90044-5. [DOI] [PubMed] [Google Scholar]
  19. Roan C., Morgan D., Paschal E. H. Urinary excretion of DDA following ingestion of DDT and DDT metabolites in man. Arch Environ Health. 1971 Mar;22(3):309–315. doi: 10.1080/00039896.1971.10665849. [DOI] [PubMed] [Google Scholar]
  20. Watson M., Benson W. W., Gabica J. Serum organochlorine pesticide levels in people in southern Idaho. Pestic Monit J. 1970 Sep;4(2):47–50. [PubMed] [Google Scholar]
  21. Wolff M. S. Occupationally derived chemicals in breast milk. Am J Ind Med. 1983;4(1-2):259–281. [PubMed] [Google Scholar]
  22. Zorgani G. A., Musa A. 0rganochlorine insecticides in the blood of occupationally exposed people in Sudan. Bull Environ Contam Toxicol. 1976 Jul;16(1):15–17. doi: 10.1007/BF01753099. [DOI] [PubMed] [Google Scholar]

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