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. 1997;75(5):427–433.

Une enquête d'efficacité vaccinale dans la ville de Bongor (Tchad) et ses conséquences opérationnelles pour le programme de vaccination.

A survey on vaccine efficacy in the city of Bongor (Chad) and its operational consequences for the vaccination program

J C Luthi 1, W Kessler 1, M Boelaert 1
PMCID: PMC2487021  PMID: 9480198

Abstract

A measles epidemic occurred in the city of Bongor, Chad, from 22 September 1993 to 26 June 1994. A total of 792 patients were hospitalized, with a case fatality rate of 5.2%. After the epidemic, the district management team evaluated the expanded programme on immunization (EPI). Through a cluster survey the attack rate was estimated to be 29.1% (95% confidence interval (CI) = 20.4-37.8%) for the age group 12-59 months (n = 206). For this same age group, the measles immunization coverage was estimated to be 44.2% (95% CI = 34.6-53.8%) and the vaccine efficacy 9.5% (95% CI = 0-41.5%). Several flaws in the logistic handling of the vaccines and especially in the cold chain were identified. These results indicated a serious management problem in the EPI, which the district team then immediately started to rectify. The method used to estimate the immunization coverage and efficacy in the study is rapid and low cost. Also, it is feasible at the district level and permits identification of management problems in the EPI.

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Selected References

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  1. Aaby P., Knudsen K., Jensen T. G., Thårup J., Poulsen A., Sodemann M., da Silva M. C., Whittle H. Measles incidence, vaccine efficacy, and mortality in two urban African areas with high vaccination coverage. J Infect Dis. 1990 Nov;162(5):1043–1048. doi: 10.1093/infdis/162.5.1043. [DOI] [PubMed] [Google Scholar]
  2. Burström B., Aaby P., Mutie D. M., Kimani G., Bjerregaard P. Severe measles outbreak in western Kenya. East Afr Med J. 1992 Aug;69(8):419–423. [PubMed] [Google Scholar]
  3. Chen R. T., Weierbach R., Bisoffi Z., Cutts F., Rhodes P., Ramaroson S., Ntembagara C., Bizimana F. A 'post-honeymoon period' measles outbreak in Muyinga sector, Burundi. Int J Epidemiol. 1994 Feb;23(1):185–193. doi: 10.1093/ije/23.1.185. [DOI] [PubMed] [Google Scholar]
  4. Cutts F. T., Dabis F. Contrôle de la rougeole dans les pays en développement. Sante. 1994 May-Jun;4(3):163–171. [PubMed] [Google Scholar]
  5. Cutts F. T., Markowitz L. E. Successes and failures in measles control. J Infect Dis. 1994 Nov;170 (Suppl 1):S32–S41. doi: 10.1093/infdis/170.supplement_1.s32. [DOI] [PubMed] [Google Scholar]
  6. Cutts F. T. Measles control in young infants: where do we go from here? Lancet. 1993 Jan 30;341(8840):290–291. doi: 10.1016/0140-6736(93)92629-8. [DOI] [PubMed] [Google Scholar]
  7. Cutts F. T., Monteiro O., Tabard P., Cliff J. Measles control in Maputo, Mozambique, using a single dose of Schwarz vaccine at age 9 months. Bull World Health Organ. 1994;72(2):227–231. [PMC free article] [PubMed] [Google Scholar]
  8. Dabis F., Sow A., Waldman R. J., Bikakouri P., Senga J., Madzou G., Jones T. S. The epidemiology of measles in a partially vaccinated population in an African city: implications for immunization programs. Am J Epidemiol. 1988 Jan;127(1):171–178. doi: 10.1093/oxfordjournals.aje.a114778. [DOI] [PubMed] [Google Scholar]
  9. Dietz V. J., Nieburg P., Gubler D. J., Gomez I. Diagnosis of measles by clinical case definition in dengue-endemic areas: implications for measles surveillance and control. Bull World Health Organ. 1992;70(6):745–750. [PMC free article] [PubMed] [Google Scholar]
  10. Hull H. F., Williams P. J., Oldfield F. Measles mortality and vaccine efficacy in rural West Africa. Lancet. 1983 Apr 30;1(8331):972–975. doi: 10.1016/s0140-6736(83)92091-3. [DOI] [PubMed] [Google Scholar]
  11. Malfait P., Jataou I. M., Jollet M. C., Margot A., De Benoist A. C., Moren A. Measles epidemic in the urban community of Niamey: transmission patterns, vaccine efficacy and immunization strategies, Niger, 1990 to 1991. Pediatr Infect Dis J. 1994 Jan;13(1):38–45. doi: 10.1097/00006454-199401000-00009. [DOI] [PubMed] [Google Scholar]
  12. Orenstein W. A., Bernier R. H., Hinman A. R. Assessing vaccine efficacy in the field. Further observations. Epidemiol Rev. 1988;10:212–241. doi: 10.1093/oxfordjournals.epirev.a036023. [DOI] [PubMed] [Google Scholar]
  13. Porter J. D., Gastellu-Etchegorry M., Navarre I., Lungu G., Moren A. Measles outbreaks in the Mozambican refugee camps in Malawi: the continued need for an effective vaccine. Int J Epidemiol. 1990 Dec;19(4):1072–1077. doi: 10.1093/ije/19.4.1072. [DOI] [PubMed] [Google Scholar]
  14. Rey J. L., Trolet C., Soro B., Cunin P., Merouze F. Difficultés de la surveillance épidémiologique de la rougeole en Afrique: exemple de la Côte d'Ivoire. Ann Soc Belg Med Trop. 1991 Jun;71(2):115–121. [PubMed] [Google Scholar]
  15. Weeks R. M., Barenzi J. F., Wayira J. R. A low-cost, community-based measles outbreak investigation with follow-up action. Bull World Health Organ. 1992;70(3):317–321. [PMC free article] [PubMed] [Google Scholar]

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