Skip to main content
PMC home page
Journal of Virology logoLink to Journal of Virology
. 1991 Aug;65(8):4378–4386. doi: 10.1128/jvi.65.8.4378-4386.1991

Nucleotide sequence analysis of Aleutian mink disease parvovirus shows that multiple virus types are present in infected mink.

E Gottschalck 1, S Alexandersen 1, A Cohn 1, L A Poulsen 1, M E Bloom 1, B Aasted 1
PMCID: PMC248877  PMID: 1649336

Abstract

Different isolates of Aleutian mink disease parvovirus (ADV) were cloned and nucleotide sequenced. Analysis of individual clones from two in vivo-derived isolates of high virulence indicated that more than one type of ADV DNA were present in each of these isolates. Analysis of several clones from two preparations of a cell culture-adapted isolate of low virulence showed the presence of only one type of ADV DNA. We also describe the nucleotide sequence from map units 44 to 88 of a new type of ADV DNA. The new type of ADV DNA is compared with the previously published ADV sequences, to which it shows 95% homology. These findings indicate that ADV, a single-stranded DNA virus, has a considerable degree of variability and that several virus types can be present simultaneously in an infected animal.

Full text

PDF
4382

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aasted B. Purification and characterization of Aleutian disease virus. Acta Pathol Microbiol Scand B. 1980 Dec;88(6):323–328. doi: 10.1111/j.1699-0463.1980.tb02650.x. [DOI] [PubMed] [Google Scholar]
  2. Alexandersen S. Acute interstitial pneumonia in mink kits: experimental reproduction of the disease. Vet Pathol. 1986 Sep;23(5):579–588. doi: 10.1177/030098588602300506. [DOI] [PubMed] [Google Scholar]
  3. Alexandersen S., Bloom M. E., Perryman S. Detailed transcription map of Aleutian mink disease parvovirus. J Virol. 1988 Oct;62(10):3684–3694. doi: 10.1128/jvi.62.10.3684-3694.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Alexandersen S., Bloom M. E. Studies on the sequential development of acute interstitial pneumonia caused by Aleutian disease virus in mink kits. J Virol. 1987 Jan;61(1):81–86. doi: 10.1128/jvi.61.1.81-86.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Alexandersen S., Bloom M. E., Wolfinbarger J. Evidence of restricted viral replication in adult mink infected with Aleutian disease of mink parvovirus. J Virol. 1988 May;62(5):1495–1507. doi: 10.1128/jvi.62.5.1495-1507.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Alexandersen S., Bloom M. E., Wolfinbarger J., Race R. E. In situ molecular hybridization for detection of Aleutian mink disease parvovirus DNA by using strand-specific probes: identification of target cells for viral replication in cell cultures and in mink kits with virus-induced interstitial pneumonia. J Virol. 1987 Aug;61(8):2407–2419. doi: 10.1128/jvi.61.8.2407-2419.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Alexandersen S., Hau J., Larsen S. Examination of Aleutian disease virus in charge-shift crossed immunoelectrophoresis. Acta Pathol Microbiol Immunol Scand B. 1984 Dec;92(6):331–334. doi: 10.1111/j.1699-0463.1984.tb02842.x. [DOI] [PubMed] [Google Scholar]
  8. Alexandersen S. Pathogenesis of disease caused by Aleutian mink disease parvovirus. APMIS Suppl. 1990;14:1–32. [PubMed] [Google Scholar]
  9. Alexandersen S., Uttenthal-Jensen A., Aasted B. Demonstration of non-degraded Aleutian disease virus (ADV) proteins in lung tissue from experimentally infected mink kits. Brief report. Arch Virol. 1986;87(1-2):127–133. doi: 10.1007/BF01310549. [DOI] [PubMed] [Google Scholar]
  10. Antonietti J. P., Sahli R., Beard P., Hirt B. Characterization of the cell type-specific determinant in the genome of minute virus of mice. J Virol. 1988 Feb;62(2):552–557. doi: 10.1128/jvi.62.2.552-557.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Astell C. R., Gardiner E. M., Tattersall P. DNA sequence of the lymphotropic variant of minute virus of mice, MVM(i), and comparison with the DNA sequence of the fibrotropic prototype strain. J Virol. 1986 Feb;57(2):656–669. doi: 10.1128/jvi.57.2.656-669.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Bloom M. E., Alexandersen S., Garon C. F., Mori S., Wei W., Perryman S., Wolfinbarger J. B. Nucleotide sequence of the 5'-terminal palindrome of Aleutian mink disease parvovirus and construction of an infectious molecular clone. J Virol. 1990 Jul;64(7):3551–3556. doi: 10.1128/jvi.64.7.3551-3556.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Bloom M. E., Alexandersen S., Perryman S., Lechner D., Wolfinbarger J. B. Nucleotide sequence and genomic organization of Aleutian mink disease parvovirus (ADV): sequence comparisons between a nonpathogenic and a pathogenic strain of ADV. J Virol. 1988 Aug;62(8):2903–2915. doi: 10.1128/jvi.62.8.2903-2915.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Bloom M. E., Kaaden O. R., Huggans E., Cohn A., Wolfinbarger J. B. Molecular comparisons of in vivo- and in vitro-derived strains of Aleutian disease of mink parvovirus. J Virol. 1988 Jan;62(1):132–138. doi: 10.1128/jvi.62.1.132-138.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Bloom M. E., Mayer L. W., Garon C. F. Characterization of the Aleutian disease virus genome and its intracellular forms. J Virol. 1983 Mar;45(3):977–984. doi: 10.1128/jvi.45.3.977-984.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Bloom M. E., Race R. E., Wolfinbarger J. B. Analysis of Aleutian disease of mink parvovirus infection using strand-specific hybridization probes. Intervirology. 1987;27(2):102–111. doi: 10.1159/000149727. [DOI] [PubMed] [Google Scholar]
  17. Bloom M. E., Race R. E., Wolfinbarger J. B. Characterization of Aleutian disease virus as a parvovirus. J Virol. 1980 Sep;35(3):836–843. doi: 10.1128/jvi.35.3.836-843.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Bloom M. E., Race R. E., Wolfinbarger J. B. Identification of a nonvirion protein of Aleutian disease virus: mink with Aleutian disease have antibody to both virion and nonvirion proteins. J Virol. 1982 Aug;43(2):608–616. doi: 10.1128/jvi.43.2.608-616.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Carlson J., Rushlow K., Maxwell I., Maxwell F., Winston S., Hahn W. Cloning and sequence of DNA encoding structural proteins of the autonomous parvovirus feline panleukopenia virus. J Virol. 1985 Sep;55(3):574–582. doi: 10.1128/jvi.55.3.574-582.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Carpenter S., Alexandersen S., Long M. J., Perryman S., Chesebro B. Identification of a hypervariable region in the long terminal repeat of equine infectious anemia virus. J Virol. 1991 Mar;65(3):1605–1610. doi: 10.1128/jvi.65.3.1605-1610.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Chen E. Y., Seeburg P. H. Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. DNA. 1985 Apr;4(2):165–170. doi: 10.1089/dna.1985.4.165. [DOI] [PubMed] [Google Scholar]
  22. Chesebro B., Bloom M., Hadlow W., Race R. Purification and ultrastructure of Aleutian disease virus of mink. Nature. 1975 Apr 3;254(5499):456–457. doi: 10.1038/254456a0. [DOI] [PubMed] [Google Scholar]
  23. Cotmore S. F., Tattersall P. The autonomously replicating parvoviruses of vertebrates. Adv Virus Res. 1987;33:91–174. doi: 10.1016/s0065-3527(08)60317-6. [DOI] [PubMed] [Google Scholar]
  24. Eklund C. M., Hadlow W. J., Kennedy R. C., Boyle C. C., Jackson T. A. Aleutian disease of mink: properties of the etiologic agent and the host responses. J Infect Dis. 1968 Dec;118(5):510–526. doi: 10.1093/infdis/118.5.510. [DOI] [PubMed] [Google Scholar]
  25. Fisher A. G., Ensoli B., Looney D., Rose A., Gallo R. C., Saag M. S., Shaw G. M., Hahn B. H., Wong-Staal F. Biologically diverse molecular variants within a single HIV-1 isolate. Nature. 1988 Aug 4;334(6181):444–447. doi: 10.1038/334444a0. [DOI] [PubMed] [Google Scholar]
  26. GORHAM J. R., LEADER R. W., HENSON J. B. THE EXPERIMENTAL TRANSMISSION OF A VIRUS CAUSING HYPERGAMMAGLOBULINEMIA IN MINK: SOURCES AND MODES OF INFECTION. J Infect Dis. 1964 Oct;114:341–345. doi: 10.1093/infdis/114.4.341. [DOI] [PubMed] [Google Scholar]
  27. Hadlow W. J., Race R. E., Kennedy R. C. Comparative pathogenicity of four strains of Aleutian disease virus for pastel and sapphire mink. Infect Immun. 1983 Sep;41(3):1016–1023. doi: 10.1128/iai.41.3.1016-1023.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Hahn E. C., Ramos L., Kenyon A. J. Expression of Aleutian mink disease antigen in cell culture. Infect Immun. 1977 Jan;15(1):204–211. doi: 10.1128/iai.15.1.204-211.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Hahn E. C., Ramos L., Kenyon A. J. Properties of Aleutian disease virus assayed with feline kidney cells. Arch Virol. 1977;55(4):315–326. doi: 10.1007/BF01315053. [DOI] [PubMed] [Google Scholar]
  30. Keohavong P., Thilly W. G. Fidelity of DNA polymerases in DNA amplification. Proc Natl Acad Sci U S A. 1989 Dec;86(23):9253–9257. doi: 10.1073/pnas.86.23.9253. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Koch W. C., Adler S. P. Detection of human parvovirus B19 DNA by using the polymerase chain reaction. J Clin Microbiol. 1990 Jan;28(1):65–69. doi: 10.1128/jcm.28.1.65-69.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Kurtzman G. J., Cohen B. J., Field A. M., Oseas R., Blaese R. M., Young N. S. Immune response to B19 parvovirus and an antibody defect in persistent viral infection. J Clin Invest. 1989 Oct;84(4):1114–1123. doi: 10.1172/JCI114274. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Larsen S., Alexandersen S., Lund E., Have P., Hansen M. Acute interstitial pneumonitis caused by Aleutian disease virus in mink kits. Acta Pathol Microbiol Immunol Scand A. 1984 Sep;92(5):391–393. doi: 10.1111/j.1699-0463.1984.tb04419.x. [DOI] [PubMed] [Google Scholar]
  34. McMaster G. K., Beard P., Engers H. D., Hirt B. Characterization of an immunosuppressive parvovirus related to the minute virus of mice. J Virol. 1981 Apr;38(1):317–326. doi: 10.1128/jvi.38.1.317-326.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Overbaugh J., Donahue P. R., Quackenbush S. L., Hoover E. A., Mullins J. I. Molecular cloning of a feline leukemia virus that induces fatal immunodeficiency disease in cats. Science. 1988 Feb 19;239(4842):906–910. doi: 10.1126/science.2893454. [DOI] [PubMed] [Google Scholar]
  36. Porter D. D. Aleutian disease: a persistent parvovirus infection of mink with a maximal but ineffective host humoral immune response. Prog Med Virol. 1986;33:42–60. [PubMed] [Google Scholar]
  37. Porter D. D., Larsen A. E., Cox N. A., Porter H. G., Suffin S. C. Isolation of Aleutian disease virus of mink in cell culture. Intervirology. 1977;8(3):129–144. doi: 10.1159/000148888. [DOI] [PubMed] [Google Scholar]
  38. Porter D. D., Larsen A. E., Porter H. G. The pathogenesis of Aleutian disease of mink. I. In vivo viral replication and the host antibody response to viral antigen. J Exp Med. 1969 Sep 1;130(3):575–593. doi: 10.1084/jem.130.3.575. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Race R. E., Chesebro B., Bloom M. E., Aasted B., Wolfinbarger J. Monoclonal antibodies against Aleutian disease virus distinguish virus strains and differentiate sites of virus replication from sites of viral antigen sequestration. J Virol. 1986 Jan;57(1):285–293. doi: 10.1128/jvi.57.1.285-293.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Reed A. P., Jones E. V., Miller T. J. Nucleotide sequence and genome organization of canine parvovirus. J Virol. 1988 Jan;62(1):266–276. doi: 10.1128/jvi.62.1.266-276.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Rhode S. L., 3rd Nucleotide sequence of the coat protein gene of canine parvovirus. J Virol. 1985 May;54(2):630–633. doi: 10.1128/jvi.54.2.630-633.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Saag M. S., Hahn B. H., Gibbons J., Li Y., Parks E. S., Parks W. P., Shaw G. M. Extensive variation of human immunodeficiency virus type-1 in vivo. Nature. 1988 Aug 4;334(6181):440–444. doi: 10.1038/334440a0. [DOI] [PubMed] [Google Scholar]
  43. Sahli R., McMaster G. K., Hirt B. DNA sequence comparison between two tissue-specific variants of the autonomous parvovirus, minute virus of mice. Nucleic Acids Res. 1985 May 24;13(10):3617–3633. doi: 10.1093/nar/13.10.3617. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Sanger F., Nicklen S., Coulson A. R. DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463–5467. doi: 10.1073/pnas.74.12.5463. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Tattersall P., Bratton J. Reciprocal productive and restrictive virus-cell interactions of immunosuppressive and prototype strains of minute virus of mice. J Virol. 1983 Jun;46(3):944–955. doi: 10.1128/jvi.46.3.944-955.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Tratschin J. D., McMaster G. K., Kronauer G., Siegl G. Canine parvovirus: relationship to wild-type and vaccine strains of feline panleukopenia virus and mink enteritis virus. J Gen Virol. 1982 Jul;61(Pt 50):33–41. doi: 10.1099/0022-1317-61-1-33. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES