Role of non-human primates in malaria vaccine development: Memorandum from a WHO Meeting

. 1988;66(6):719–728.

Role of non-human primates in malaria vaccine development: Memorandum from a WHO Meeting^{^*}

This Memorandum is based on the report of a consultation on the role of non-human primates in malaria vaccine development which was held, under the auspices of the Scientific Working Group on the Immunology of Malaria of the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), in Geneva, Switzerland, on 18-19 April 1988. A summary in French appears on pages 727-728. Requests for reprints should be sent to the Office of the Director, TDR, World Health Organization, 1211 Geneva 27, Switzerland. The participants at this consultation were: R. F. Anders, Melbourne, Victoria, Australia; R. Aquino, Iquitos, Peru; J. W. Barnwell, New York, NY, USA; D. F. Clyde, Baltimore, MD, USA; W. E. Collins, Atlanta, GA, USA; D. Davidson, Washington, DC, USA; M. M. Dhar, Lucknow, UP, India; J. D. Haynes, Washington, DC, USA; H. G. Heidrich, Martinsried bei München, Federal Republic of Germany; A. A. Holder, London, England; R. Howard, Palo Alto, CA, USA; D. T. Liu, Bethesda, MD, USA; K. N. Mendis, Colombo, Sri Lanka; L. Pereira da Silva, Paris, France; P. Perlmann, Stockholm, Sweden; L. H. Perrin, Geneva, Switzerland; R. S. Phillips, Glasgow, Scotland; T. B. Poole, Potters Bar, England; R. T. Reese, La Jolla, CA, USA; P. Reeve, Redwood City, CA, USA; J. Richmond, Cupar, Fife, Scotland; R. G. Ridley, Edinburgh, Scotland; T. Ruebush, Atlanta, GA, USA; H. Schellekens, Delft, Netherlands; W. A. Siddiqui, Honolulu, HI, USA; R. A. Whitney, Bethesda, MD, USA. Observers: M. Aikawa, Cleveland, OH, USA; W. R. S. Briggs, Melbourne, Victoria, Australia; M. Cagnard, Lyon, France; J. Chulay, Washington, DC, USA; P. Crooy, Philadelphia, PA, USA; S. J. Cryz, Bern, Switzerland; P. David, Paris, France; B. Enders, Marburg, Federal Republic of Germany; H. Etlinger, Basle, Switzerland; S. Fairfield, Washington, DC, USA; J. Gysin, Cayenne, French Guiana; W. Hockmeyer, Rochester, NY, USA; J. Heiby, Washington, DC, USA; C. Miller, Washington, DC, USA; B. Mons, Leiden, Netherlands; J. R. L. Pink, Basle, Switzerland; M. Ristic, Urbana, IL, USA; D. Snary, Beckenham, England; H. J. van der Kaay, Leiden, Netherlands; R. Weller, Richland, WA, USA; P. Winter, Arlington, VA, USA. WHO Secretariat: P. V. Arambulo and J. R. Held, WHO Regional Office for the Americas, Washington, DC, USA; P.-H. Lambert, L. Martinez and W. H. Wernsdorfer, World Health Organization, Geneva, Switzerland. Special thanks are due to Dr T. Ruebush for help in finalizing this report.

PMCID: PMC2491147 PMID: 3266112

Abstract

This Memorandum discusses the coordination and standardization of malaria vaccine research in non-human primates to encourage optimum use of the available animals in experiments that are fully justified both scientifically and ethically. The requirements for experimentation in non-human primates, the availability of suitable animals for malaria vaccine studies, and the criteria for testing candidate vaccines are considered. The policy and legislation relevant to the use of non-human primates in biomedical research are also briefly discussed. The Memorandum concludes with eight recommendations.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

Collins W. E., Anders R. F., Pappaioanou M., Campbell G. H., Brown G. V., Kemp D. J., Coppel R. L., Skinner J. C., Andrysiak P. M., Favaloro J. M. Immunization of Aotus monkeys with recombinant proteins of an erythrocyte surface antigen of Plasmodium falciparum. Nature. 1986 Sep 18;323(6085):259–262. doi: 10.1038/323259a0. [DOI] [PubMed] [Google Scholar]
Collins W. E., Campbell C. C., Skinner J. C., Chin W., Nguyen-Dinh P., Huong A. Y. Studies on the Indochina I/CDC strain of Plasmodium falciparum in Colombian and Bolivian Aotus monkeys and different anophelines. J Parasitol. 1983 Feb;69(1):186–190. [PubMed] [Google Scholar]
Collins W. E., Pappaioanou M., Anders R. F., Campbell G. H., Brown G. V., Kemp D. J., Broderson J. R., Coppel R. L., Skinner J. C., Procell P. M. Immunization trials with the ring-infected erythrocyte surface antigen of Plasmodium falciparum in owl monkeys (Aotus vociferans). Am J Trop Med Hyg. 1988 Mar;38(2):268–282. doi: 10.4269/ajtmh.1988.38.268. [DOI] [PubMed] [Google Scholar]
Ma N. S., Jones T. C., Miller A. C., Morgan L. M., Adams E. A. Chromosome polymorphism and banding patterns in the owl monkey (Aotus). Lab Anim Sci. 1976 Dec;26(6 Pt 2):1022–1036. [PubMed] [Google Scholar]
Patarroyo M. E., Romero P., Torres M. L., Clavijo P., Moreno A., Martínez A., Rodríguez R., Guzman F., Cabezas E. Induction of protective immunity against experimental infection with malaria using synthetic peptides. Nature. 1987 Aug 13;328(6131):629–632. doi: 10.1038/328629a0. [DOI] [PubMed] [Google Scholar]

[OCR_01187] Collins W. E., Anders R. F., Pappaioanou M., Campbell G. H., Brown G. V., Kemp D. J., Coppel R. L., Skinner J. C., Andrysiak P. M., Favaloro J. M. Immunization of Aotus monkeys with recombinant proteins of an erythrocyte surface antigen of Plasmodium falciparum. Nature. 1986 Sep 18;323(6085):259–262. doi: 10.1038/323259a0. [DOI] [PubMed] [Google Scholar]

[OCR_01171] Collins W. E., Campbell C. C., Skinner J. C., Chin W., Nguyen-Dinh P., Huong A. Y. Studies on the Indochina I/CDC strain of Plasmodium falciparum in Colombian and Bolivian Aotus monkeys and different anophelines. J Parasitol. 1983 Feb;69(1):186–190. [PubMed] [Google Scholar]

[OCR_01199] Collins W. E., Pappaioanou M., Anders R. F., Campbell G. H., Brown G. V., Kemp D. J., Broderson J. R., Coppel R. L., Skinner J. C., Procell P. M. Immunization trials with the ring-infected erythrocyte surface antigen of Plasmodium falciparum in owl monkeys (Aotus vociferans). Am J Trop Med Hyg. 1988 Mar;38(2):268–282. doi: 10.4269/ajtmh.1988.38.268. [DOI] [PubMed] [Google Scholar]

[OCR_01166] Ma N. S., Jones T. C., Miller A. C., Morgan L. M., Adams E. A. Chromosome polymorphism and banding patterns in the owl monkey (Aotus). Lab Anim Sci. 1976 Dec;26(6 Pt 2):1022–1036. [PubMed] [Google Scholar]

[OCR_01194] Patarroyo M. E., Romero P., Torres M. L., Clavijo P., Moreno A., Martínez A., Rodríguez R., Guzman F., Cabezas E. Induction of protective immunity against experimental infection with malaria using synthetic peptides. Nature. 1987 Aug 13;328(6131):629–632. doi: 10.1038/328629a0. [DOI] [PubMed] [Google Scholar]

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Role of non-human primates in malaria vaccine development: Memorandum from a WHO Meeting^{^*}