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. 1990 Mar;64(3):1353–1356. doi: 10.1128/jvi.64.3.1353-1356.1990

Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein.

N Dyson 1, R Bernards 1, S H Friend 1, L R Gooding 1, J A Hassell 1, E O Major 1, J M Pipas 1, T Vandyke 1, E Harlow 1
PMCID: PMC249255  PMID: 2154613

Abstract

Stable protein complexes between the large T antigens of mouse, monkey, baboon, or human polyomaviruses and the retinoblastoma protein were detected by an in vitro coimmunoprecipitation assay. All of the large T antigens tested were able to bind to both human and mouse retinoblastoma polypeptides, showing that these interactions have been conserved during evolution.

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Selected References

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