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. 1972 Nov;48(565):673–677. doi: 10.1136/pgmj.48.565.673

Coeliac disease and small bowel carcinoma

Simon Kenwright
PMCID: PMC2495314  PMID: 4650781

Abstract

Small bowel carcinoma can occur in association with villous atrophy in the jejunum. In most reported cases there is doubt as to which of these represents the primary lesion. These cases are reviewed here. A further case is reported in which a carcinoma developed in a patient known to be suffering from coeliac disease for some years, although he was not on a gluten-free diet for the time preceding the diagnosis of carcinoma. On dietary restriction he remains well at 2-year follow-up. Possible aetiological factors are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Asquith P., Thompson R. A., Cooke W. T. Serum-immunoglobulins in adult coeliac disease. Lancet. 1969 Jul 19;2(7612):129–131. doi: 10.1016/s0140-6736(69)92440-4. [DOI] [PubMed] [Google Scholar]
  2. Blecher T. E., Brzechwa-Ajdukiewicz A., McCarthy C. F., Read A. E. Serum immunoglobulins and lymphocyte transformation studies in coeliac disease. Gut. 1969 Jan;10(1):57–62. doi: 10.1136/gut.10.1.57. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brookes V. S., Waterhouse J. A., Powell D. J. Malignant lesions of the small intestine: a ten-year survey. Br J Surg. 1968 Jun;55(6):405–410. doi: 10.1002/bjs.1800550602. [DOI] [PubMed] [Google Scholar]
  4. Brunt P. W., Sircus W., Maclean N. Neoplasia and the coeliac syndrome in adults. Lancet. 1969 Jan 25;1(7587):180–184. doi: 10.1016/s0140-6736(69)91192-1. [DOI] [PubMed] [Google Scholar]
  5. Brzechwa-Ajdukiewicz A., McCarthy C. F., Austad W., Cornes J., Harrison W. J., Read A. E. Carcinoma, villous atrophy, and steatorrhoea. Gut. 1966 Dec;7(6):572–577. doi: 10.1136/gut.7.6.572. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. CREAMER B. Dynamics of the mucosa of the small intestine in idiopathic steatorrhoea. Gut. 1962 Dec;3:295–300. doi: 10.1136/gut.3.4.295. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. CREAMER B. MALIGNANCY AND THE SMALL-INTESTINAL MUCOSA. Br Med J. 1964 Dec 5;2(5422):1435–1436. doi: 10.1136/bmj.2.5422.1435. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. FRIC P., BEDNAR B., NIEDERLE B., LEPSIK J. Jejunal adenocarcinoma in a woman with nontropical sprue. Gastroenterology. 1963 Mar;44:330–334. [PubMed] [Google Scholar]
  9. GIRDWOOD R. H., DELAMORE I. W., WILLIAMS A. W. Jejunal biopsy in malabsorptive disorders of the adult. Br Med J. 1961 Feb 4;1(5222):319–323. doi: 10.1136/bmj.1.5222.319. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. HINDLE W., CREAMER B. CLINICAL PICTURE ACCOMPANYING A FLAT SMALL-INTESTINAL MUCOSA. Br Med J. 1965 Aug 21;2(5459):458–459. doi: 10.1136/bmj.2.5459.458. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Haffner J. F., Semb L. S. Malignant tumours of the small intestine. Acta Chir Scand. 1969;135(6):543–548. [PubMed] [Google Scholar]
  12. Harris O. D., Cooke W. T., Thompson H., Waterhouse J. A. Malignancy in adult coeliac disease and idiopathic steatorrhoea. Am J Med. 1967 Jun;42(6):899–912. doi: 10.1016/0002-9343(67)90071-x. [DOI] [PubMed] [Google Scholar]
  13. Hennessy W. B., Ralston M. Ileocaecal carcinoma and the coeliac syndrome. Gut. 1969 Nov;10(11):951–952. [PubMed] [Google Scholar]
  14. JOSKE R. A. Primary carcinoma of the jejunum with atrophic jejunitis and intestinal malabsorption. Gastroenterology. 1960 May;38:810–816. [PubMed] [Google Scholar]
  15. Kenrick K. G., Walker-Smith J. A. Immunoglobulins and dietary protein antibodies in childhood coeliac disease. Gut. 1970 Aug;11(8):635–640. doi: 10.1136/gut.11.8.635. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Kissel P., Rauber G., Barrucand D., Marchal C., Leclère J. Adénocarcinome du grêle dans l'évolution d'une maladie coeliaque de l'adulte. Arch Mal Appar Dig Mal Nutr. 1965 Sep;54(9):945–951. [PubMed] [Google Scholar]
  17. MOERTEL C. G., HARGRAVES M. M. Coexistence of adenocarcinoma of the jejunum and nontropical sprue. JAMA. 1961 May 20;176:612–614. doi: 10.1001/jama.1961.63040200015016a. [DOI] [PubMed] [Google Scholar]
  18. Maclaurin B. P., Cooke W. T., Ling N. R. Impaired lymphocyte reactivity against tumour cells in patients with coeliac disease. Gut. 1971 Oct;12(10):794–800. doi: 10.1136/gut.12.10.794. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. OGILVIE T. A., SHAW H. M. Primary tumours of the small bowel. Br Med J. 1955 Jan 15;1(4906):142–145. doi: 10.1136/bmj.1.4906.142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. SOUTHAM J. A. Primary malignant tumours of the jejunum and ileum. Br J Surg. 1963 Jan;50:393–399. doi: 10.1002/bjs.18005022208. [DOI] [PubMed] [Google Scholar]
  22. Wright J. T., Richardson P. C. Squamous carcinoma of the thoracic oesophagus in malabsorption syndrome. Br Med J. 1967 Mar 4;1(5539):540–542. doi: 10.1136/bmj.1.5539.540. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Wyatt A. P. Regional enteritis leading to carcinoma of the small bowel. Gut. 1969 Nov;10(11):924–927. doi: 10.1136/gut.10.11.924. [DOI] [PMC free article] [PubMed] [Google Scholar]

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