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. 1990 Jul;64(7):3532–3536. doi: 10.1128/jvi.64.7.3532-3536.1990

Human cytomegalovirus immediate-early two protein region involved in negative regulation of the major immediate-early promoter.

T W Hermiston 1, C L Malone 1, M F Stinski 1
PMCID: PMC249624  PMID: 2161955

Abstract

The immediate-early two (IE2) gene products of human cytomegalovirus negatively regulate gene expression from the major immediate-early promoter in permissive human fibroblasts. A mutational analysis of the IE2 proteins indicated that the carboxyl-terminal region is required for negative regulation. The IE2 proteins that lack amino acid residues 365 to 519, or the carboxyl-terminal amino acids failed to negatively regulate. Most of the amino-terminal portion of the IE2 protein was not required for negative regulation. A possible explanation of the negative effect on downstream expression by the IE2 proteins is discussed.

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Selected References

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