Abstract
A case of hyponatraemic coma occurring in a patient with diabetes mellitus treated with tolbutamide is described. Although chlorpropamide is known to cause water retention in some circumstances, this is a less well recognized complication of tolbutamide therapy.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Fichman M. P., Brooker G. Deficient renal cyclic adenosine 3'-5' monophosphate production in nephrogenic diabetes insipidus. J Clin Endocrinol Metab. 1972 Jul;35(1):35–47. doi: 10.1210/jcem-35-1-35. [DOI] [PubMed] [Google Scholar]
- Hagen G. A., Frawley T. F. Hyponatremia due to sulfonylurea compounds. J Clin Endocrinol Metab. 1970 Nov;31(5):570–576. doi: 10.1210/jcem-31-5-570. [DOI] [PubMed] [Google Scholar]
- Miller M., Moses A. M. Mechanism of chlorpropamide action in diabetes insipidus. J Clin Endocrinol Metab. 1970 Apr;30(4):488–496. doi: 10.1210/jcem-30-4-488. [DOI] [PubMed] [Google Scholar]
- Moses A. M., Howanitz J., Miller M. Diuretic action of three sulfonylurea drugs. Ann Intern Med. 1973 Apr;78(4):541–544. doi: 10.7326/0003-4819-78-4-541. [DOI] [PubMed] [Google Scholar]
- Webster B., Bain J. Antidiuretic effect and complications of chlorpropamide therapy in diabetes insipidus. J Clin Endocrinol Metab. 1970 Feb;30(2):215–227. doi: 10.1210/jcem-30-2-215. [DOI] [PubMed] [Google Scholar]
- Weissman P. N., Shenkman L., Gregerman R. I. Chlorpropamide hyponatremia: drug-induced inappropriate antidiuretic-hormone activity. N Engl J Med. 1971 Jan 14;284(2):65–71. doi: 10.1056/NEJM197101142840202. [DOI] [PubMed] [Google Scholar]